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Cenicriviroc

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Purity:98.98%

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COA HNMR HPLC

Cenicriviroc

Catalog No. TQ0297Cas No. 497223-25-3

Cenicriviroc (TAK-652) is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory activity.

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Pack Size	Price	Availability
1 mg	$63	In Stock
2 mg	$90	In Stock
5 mg	$129	In Stock
10 mg	$205	In Stock
25 mg	$412	In Stock
50 mg	$532	In Stock
100 mg	$768	In Stock
200 mg	$1,080	In Stock
1 mL x 10 mM (in DMSO)	$221	In Stock

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Product Introduction

Bioactivity

Description	Cenicriviroc (TAK-652) is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory activity.
In vitro	Cenicriviroc prevents HIV-1 from cellular entry [2]. Regarding the 4 R5 HIV-2 clinical isolates tested, effective concentration 50% EC50 for cenicriviroc are 0.03, 0.33, 0.45 and 0.98 nM. The dual-tropic and the X4-tropic HIV-2 strains are resistant to cenicriviroc with EC50 at >1000 nM, and MPI at 33% and 4%, respectively [3].
In vivo	Cenicriviroc (≥20 mg/kg/day) significantly reduces monocyte/macrophage recruitment in vivo. In the NASH model, cenicriviroc significantly reduces the non-alcoholic fatty liver disease activity score. Cenicriviroc treatment has no notable effect on body or liver/kidney weight [1].
Animal Research	Male C57BL/6 mice (n=44; 8-10 weeks of age) are allocated to receive treatments via oral gavage (PO) on Days 1-5 in the following groups: non-disease control, vehicle control twice daily (BID), Cenicriviroc 5 mg/kg/day (Cenicriviroc5) BID, Cenicriviroc 20 mg/kg/day (Cenicriviroc20) BID, Cenicriviroc 100 mg/kg/day (Cenicriviroc100) BID, Cenicriviroc20 QD, and positive control (corticosteroid known to reduce inflammation in a variety of animal models) 1 mg/kg QD. On Day 4, peritonitis is induced via IP injection of TG 3.85% (1 mL/animal) 2 hours post-dose in all groups except non-disease controls [1].
Alias	TAK-652, TBR-652

Chemical Properties

Molecular Weight	696.94
Formula	C41H52N4O4S
Cas No.	497223-25-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (172.19 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4348 mL	7.1742 mL	14.3484 mL	71.7422 mL
5 mM	0.2870 mL	1.4348 mL	2.8697 mL	14.3484 mL
10 mM	0.1435 mL	0.7174 mL	1.4348 mL	7.1742 mL
20 mM	0.0717 mL	0.3587 mL	0.7174 mL	3.5871 mL
50 mM	0.0287 mL	0.1435 mL	0.2870 mL	1.4348 mL
100 mM	0.0143 mL	0.0717 mL	0.1435 mL	0.7174 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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