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Etidronic acid

Catalog No. T0308 CAS 2809-21-4

Synonyms: HEDPA, Etidronate, HEDP

Etidronic acid (HEDP) is a diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.

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Etidronic acid, CAS 2809-21-4

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500 mg	In stock	$ 41.00
1 g	In stock	$ 66.00

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Purity: 98%

Purity: 96.73%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Etidronic acid (HEDP) is a diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
In vitro	Etidronate inhibits directly osteoclastic bone-resorbing activity by pit assay. Etidronate also directly induces apoptosis and disrupts actin rings in osteoclasts. [1]
In vivo	Etidronate, when administered s.c. repeatedly at 10 or 40 mg/kg/day, gradually suppresses the adjuvant-induced allodynia In the rats with adjuvant arthritis, as assessed by 10-g von Frey hair. Etidronate (10-40 mg/kg/day) suppresses the adjuvant-induced mechanical allodynia in rat hindpaw. Etidronate (5–10 mg/kg/day) dose-dependently prevents the decrease in bone mineral density (BMD) in the proximal tibia of the arthritic rats. [2] Etidronate inhibits the histidine decarboxylase induction, but not the other inflammatory reactions induced by alendronate. Etidronate (unlike clodronate) also inhibits alendronate-induced BP-line formation in mice (even at 40 mmol/kg). Etidronate (160 mmol/kg) also inhibits the physicochemical changes in the tibia induced by six, weekly injections of alendronate. [3] Etidronate (10 mg/kg) combined with Calcitriol after subtotal nephrectomy (SNx) significantly inhibits thoracic and abdominal aortic calcification 3 weeks after the operation in rats. [4] Etidronate (5 mg/kg or 10 mg/kg) significantly reduces the thoracic and abdominal aortic calcification induced by calcitriol in the renal failure rat. Etidronate (5 mg/kg or 10 mg/kg) also reduces the dysfunction in aortic contraction. Etidronate (5 mg/kg) reverses the reduction in the aortic expression of matrix Gla protein mRNA observed in nephrectomized rats. [5]

Synonyms	HEDPA, Etidronate, HEDP
Molecular Weight	206.03
Formula	C2H8O7P2
CAS No.	2809-21-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (218.41 mM)

References and Literature

1. Hiroi-Furuya E, et al. Calcif Tissue Int, 1999, 64(3), 219-223. 2. Kawabata A, et al. Neuropharmacology, 2006, 51(2), 182-190. 3. Funayama H, et al. Calcif Tissue Int, 2005, 76(6), 448-457. 4. Tamura K, et al. J Pharmacol Sci, 2005, 99(1), 89-94. 5. Tamura K, et al. Eur J Pharmacol, 2007, 558(1-3), 159-166.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library FDA-Approved Drug Library Drug-induced Liver Injury (DILI) Compound Library Human Metabolite Library Metabolism Compound Library

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Keywords

Etidronic acid 2809-21-4 Apoptosis Metabolism Microbiology/Virology Others Phosphatase HBV inhibit Paget's disease HEDPA Etidronate osteoporosis Inhibitor MCF-7 HEDP arterial calcification inhibitor

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