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GW 441756
GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.
Catalog No. T6052Cas No. 504433-23-2
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Purity:99.8%
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GW 441756
Catalog No. T6052Cas No. 504433-23-2
GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $51 | In Stock | |
| 10 mg | $80 | In Stock | |
| 25 mg | $155 | In Stock | |
| 50 mg | $237 | In Stock | |
| 100 mg | $359 | In Stock | |
| 500 mg | $849 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $57 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM. |
| Targets&IC50 | TrkA:2 nM |
| In vivo | GW441756 inhibits γH2AX production mediated by TrkA and apoptosis in cells overexpressing TrkA. It specifically blocks TrkA-induced cell death in a dose-dependent manner. |
| Molecular Weight | 275.3 |
| Formula | C17H13N3O |
| Cas No. | 504433-23-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 18.33 mg/mL (66.59 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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