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Imeglimin hydrochloride

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Purity:100%

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COA HPLC HNMR

Imeglimin hydrochloride

Catalog No. T7486Cas No. 775351-61-6

Imeglimin hydrochloride (EMD 387008 hydrochloride) prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.

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Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$48	In Stock
5 mg	$79	In Stock
10 mg	$126	In Stock
25 mg	$229	In Stock
50 mg	$383	In Stock
100 mg	$578	In Stock
500 mg	$1,220	In Stock
1 mL x 10 mM (in DMSO)	$217	In Stock

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Product Introduction

Bioactivity

Description	Imeglimin hydrochloride (EMD 387008 hydrochloride) prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.
In vitro	Imeglimin dramatically decreased reactive oxygen species production, inhibiting specifically reverse electron transfer through complex I. Imeglimin prevents hyperglycemia-induced cell death in HMEC-1 through inhibition of PTP opening without inhibiting mitochondrial respiration nor affecting cellular energy status[1].
Alias	EMD 387008 hydrochloride

Chemical Properties

Molecular Weight	191.66
Formula	C6H14ClN5
Cas No.	775351-61-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (286.97 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2176 mL	26.0879 mL	52.1757 mL	260.8786 mL
5 mM	1.0435 mL	5.2176 mL	10.4351 mL	52.1757 mL
10 mM	0.5218 mL	2.6088 mL	5.2176 mL	26.0879 mL
20 mM	0.2609 mL	1.3044 mL	2.6088 mL	13.0439 mL
50 mM	0.1044 mL	0.5218 mL	1.0435 mL	5.2176 mL
100 mM	0.0522 mL	0.2609 mL	0.5218 mL	2.6088 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Imeglimin hydrochloride

Imeglimin hydrochloride