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Isavuconazole

Catalog No. T2305 CAS 241479-67-4

Synonyms: BAL-4815, RO-0094815

Isavuconazole (RO-0094815)(BAL-4815; RO-0094815) is the active component of the new azole antifungal agent BAL8557 with MIC(50)s/MIC(90)s ranged from 0.002/0.004 mg/liter for C. albicans to 0.25/0.5 mg/liter for C. glabrata.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Isavuconazole, CAS 241479-67-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 71.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 178.00
50 mg	In stock	$ 289.00
100 mg	In stock	$ 428.00
200 mg	In stock	$ 623.00
500 mg	In stock	$ 969.00
1 mL * 10 mM (in DMSO)	In stock	$ 78.00

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Purity: 100%

Purity: 99.97%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Kinase Assay

SP2509 activity assays: Test compounds are diluted to 20 × the desired test concentration in 100% DMSO and 2.5?μL of the diluted drug sampleis added to a black 384-well plate. The LSD1 enzyme stock is diluted 17-fold with assay buffer and 40?μL of the diluted LSD1 enzyme is added to the appropriate wells. Substrate, consisting of horseradish peroxidase, dimethyl K4 peptide corresponding to the first 21 amino acids of the N-terminal tail of histone H3, and 10-acetyl-3,7-dihydroxyphenoxazine is then added to wells. Resorufin is analyzed on an Envision plate reader with an excitation wavelength of 530?nm and an emission wavelength of 595?nm. The activity of SP2509 on the other oxidases is determined by using commercially available kits. The glucose oxidase activity (which also noncovalently binds FAD in an elongate conformation), is determined using the glucose oxidase kit. The MAO assays are performed using the MAO-glo kit with MAO-A and MAO-B.

Synonyms	BAL-4815, RO-0094815
Molecular Weight	437.47
Formula	C22H17F2N5OS
CAS No.	241479-67-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 70 mg/mL (160.01 mM)

References and Literature

1. Seifert H, et al. Antimicrob Agents ChemOthers. 2007 May;51(5):1818-21. 2. Lau S K P, Xing F, Tsang C C, et al. Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China[J]. Mycoses. 2019 May;62(5):450-457. 3. Tsang C C, Tang J Y M, Ye H, et al. Rare/cryptic Aspergillus species infections and importance of antifungal susceptibility testing[J]. Mycoses. 2020, 63(12): 1283-1298. 4. Tsang C C, Chan K F, Chan W, et al. Hepatic phaeohyphomycosis due to a novel dematiaceous fungus, Pleurostoma hongkongense sp. nov., and importance of antifungal susceptibility testing[J]. Emerging Microbes & Infections. 2020: 1-53. 5. Tsang C C, Tang J Y M, Chan K F, et al. Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing[J]. Emerging microbes & infections. 2019;8(1):531-541.

Citations

1. Ma L, Lian Y, Tang J, et al. Identification of the Anti-Fungal Drug Fenticonazole Nitrate as a Novel PPARγ-Modulating Ligand With Good Therapeutic Index: Structure-Based Screening and Biological Validation. Pharmacological Research. 2021: 105860. 2. Quan C, Chen Y, Wang X, et al. Loss of histone lysine methyltransferase EZH2 confers resistance to tyrosine kinase inhibitors in non-small cell lung cancer. Cancer Letters. 2020 3. Tsang C C, Tang J Y M, Chan K F, et al. Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing. Emerging Microbes & Infections. 2019, 8(1): 531-541 4. Tsang C C, Chan K F, Chan W, et al. Hepatic phaeohyphomycosis due to a novel dematiaceous fungus, Pleurostoma hongkongense sp. nov., and importance of antifungal susceptibility testing. Emerging Microbes & Infections. 2021 Dec;10(1):81-96. 5. Lau S K P, Xing F, Tsang C C, et al. Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China. Mycoses. 2019, 62(5): 450-457

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library EMA Approved Drug Library Drug Repurposing Compound Library Inhibitor Library Antibiotics Library Bioactive Compounds Library Max Anti-Aging Compound Library ReFRAME Related Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Isavuconazole 241479-67-4 Metabolism Microbiology/Virology P450 Antibiotic Antifungal prodrug dimorphic Inhibitor ergosterol CYPs RO 0094815 triazole BAL4815 biosynthesis Fungal fungi RO0094815 yeasts BAL-4815 inhibit BAL 4815 Cytochrome P450 RO-0094815 molds inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.