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Ispronicline
Ispronicline (TC-1734) An orally active, selective, and potent α4β2 nAChR partial agonist with antidepressant, neuroprotective, and long-lasting cognitive effects.Ispronicline has a high affinity for the α4β2 nAChR with a Ki= 11 nM.
Catalog No. T27636Cas No. 252870-53-4
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Purity:96.54%
ee:98.18%
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Ispronicline
Catalog No. T27636Alias TC-1734-112, TC-01734, TC 1734, RJR-1734, AZD-3480, AZD3480, AZD 3480Cas No. 252870-53-4
Ispronicline (TC-1734) An orally active, selective, and potent α4β2 nAChR partial agonist with antidepressant, neuroprotective, and long-lasting cognitive effects.Ispronicline has a high affinity for the α4β2 nAChR with a Ki= 11 nM.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $38 | In Stock | |
| 5 mg | $60 | In Stock | |
| 10 mg | $89 | In Stock | |
| 25 mg | $156 | In Stock | |
| 50 mg | $222 | In Stock | |
| 100 mg | $328 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $67 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ispronicline (TC-1734) An orally active, selective, and potent α4β2 nAChR partial agonist with antidepressant, neuroprotective, and long-lasting cognitive effects.Ispronicline has a high affinity for the α4β2 nAChR with a Ki= 11 nM. |
| In vivo | In rats, the subcutaneous administration of Ispronicline (10-20 mg/kg) leads to the induction of c-Fos expression in specific regions of the forebrain[1]. The pharmacokinetics of Ispronicline, characterized by a half-life of 2 hours in rats, contrasts with the sustained enhancement of working memory, lasting from 18 hours to 2 days[2]. |
| Alias | TC-1734-112, TC-01734, TC 1734, RJR-1734, AZD-3480, AZD3480, AZD 3480 |
| Molecular Weight | 234.34 |
| Formula | C14H22N2O |
| Cas No. | 252870-53-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (213.37 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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