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Ixabepilone

Catalog No. T6864   CAS 219989-84-1
Synonyms: BMS 247550, Ixempra, Azaepothilone B, BMS 247550-1

Ixabepilone (Azaepothilone B) is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Ixabepilone Chemical Structure
Ixabepilone, CAS 219989-84-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 52.00
2 mg In stock $ 94.00
5 mg In stock $ 198.00
10 mg In stock $ 363.00
25 mg In stock $ 590.00
50 mg In stock $ 857.00
100 mg In stock $ 1,150.00
200 mg In stock $ 1,550.00
1 mL * 10 mM (in DMSO) In stock $ 229.00
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Purity: 98.60%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ixabepilone (Azaepothilone B) is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis.
In vitro BMS-247550 is a highly potent cytotoxic agent capable of killing cancer cells at low nanomolar concentrations as well as retains its antineoplastic activity against human cancers that are naturally insensitive to paclitaxel or that have developed resistance to paclitaxel[1].
In vivo In vivo, BMS-247550 has clearly demonstrated antitumor activity that is superior to paclitaxel in both paclitaxel-resistant and -sensitive tumors. BMS-247550 is more efficacious compared to paclitaxel in all five paclitaxel-resistant tumors evaluated in this study (four human and one murine): i.e., the clinically derived paclitaxel resistant Pat-7 ovarian carcinoma, the A2780Tax ovarian carcinoma that is resistant to paclitaxel because of tubulin mutations, the HCT116/VM46 MDR colon carcinoma, the clinically derived paclitaxel-resistant Pat-21 breast carcinoma, and the murine fibrosarcoma M5076. Against three paclitaxel-sensitive human tumor xenografts, BMS-247550 produces antitumor activity equivalent to paclitaxel: i.e., A2780 human ovarian carcinoma, HCT116, and LS174T human colon carcinoma[1].
Kinase Assay The potency with which BMS-247550 and paclitaxel polymerize tubulin isolated from calf brain is evaluated by Published techniques. Briefly, different concentrations of paclitaxel or BMS-247550 in polymerization buffer [0.1?M mes, 1 mM?EGTA, 0.5 mM?MgCl2 (pH 6.6)] are added to tubulin in polymerization buffer at 37°C in microcuvette wells of a Beckman. Model DU 7400 UV spectrophotometer. A final microtubule protein concentration of 1.0 mg/mL and compound concentrations of generally 2.5, 5.0, and 10 μM?are used. Initial slopes of absorbance (A280 nM) change, measured every 10 s, are calculated by the software program accompanying the instrument.
Cell Research HCT116 cells from cultures are collected by trypsinization after 1, 2, 4, 8, 16, and 24 h exposure to 7.5 nm of BMS-247550. Cells are pelleted and fixed in 80% ethanol at −20°C. After an overnight storage at −20°C, cells are rehydrated with PBS buffer and DNA stain by incubation with propidium iodide (5 μg/ml) in 0.1% RNase for 15–30 min. Fluorescence-activated cell sorter acquisition is performed using the FACS Calibur instrument and analysis is done using Cellquest and Modfit software. (Only for Reference)
Synonyms BMS 247550, Ixempra, Azaepothilone B, BMS 247550-1
Molecular Weight 506.7
Formula C27H42N2O5S
CAS No. 219989-84-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 93 mg/mL (183.5 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 93 mg/mL (183.5 mM)

TargetMolReferences and Literature

1. Lee FY, et al. Clin Cancer Res. 2001, 7(5):1429-1437.

TargetMolCitations

1. Wang M, Wang J, Tsui A Y P, et al. Mechanisms of peripheral neurotoxicity associated with four chemotherapy drugs using human induced pluripotent stem cell-derived peripheral neurons. Toxicology in Vitro. 2021: 105233. 2. Wang D, Wang Y, Di X, et al.Cortical tension drug screen links mitotic spindle integrity to Rho pathway.Current Biology.2023

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Microtubule-Targeted Compound Library Clinical Compound Library Anti-Lung Cancer Compound Library Anti-Liver Cancer Compound Library Anti-Ovarian Cancer Compound Library Anti-Breast Cancer Compound Library

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Keywords

Ixabepilone 219989-84-1 Apoptosis Cytoskeletal Signaling Microtubule Associated inhibit BMS247550 Inhibitor Aza-epothilone B BMS 247550 Ixempra Azaepothilone B Microtubule/Tubulin BMS-247550 BMS 247550-1 inhibitor

 

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