Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JNJ-37822681 dihydrochloride is a novel, highly selective dopamine D₂ receptor antagonist characterized by a rapid dissociation rate from the dopamine D₂ receptor. JNJ-37822681 dihydrochloride shows a moderate binding affinity for the dopamine D2L receptor with a Ki of 158 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 56.00 | |
5 mg | In stock | $ 116.00 | |
10 mg | In stock | $ 163.00 | |
25 mg | In stock | $ 270.00 | |
50 mg | In stock | $ 398.00 | |
100 mg | In stock | $ 593.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 141.00 |
Description | JNJ-37822681 dihydrochloride is a novel, highly selective dopamine D₂ receptor antagonist characterized by a rapid dissociation rate from the dopamine D₂ receptor. JNJ-37822681 dihydrochloride shows a moderate binding affinity for the dopamine D2L receptor with a Ki of 158 nM. |
Targets&IC50 | D2:0.39 mg/kg(ED50), D2:158 nM(Ki) |
In vivo | JNJ-37822681 dihydrochloride occupied D2 receptors in rat brain at relatively low doses (ED50 = 0.39 mg/kg) and was effective in animal models of psychosis (e.g., inhibition of apomorphine-induced stereotypy or D-amphetamine/phencyclidine-induced hyperlocomotion)[4]. |
Molecular Weight | 445.26 |
Formula | C17H19Cl2F5N4 |
CAS No. | 2108806-02-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33.33 mg/mL (74.86 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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JNJ-37822681 dihydrochloride 2108806-02-4 GPCR/G Protein Neuroscience Dopamine Receptor d-amphetamine phencyclidine JNJ-37822681 Dihydrochloride JNJ37822681 Dihydrochloride JNJ 37822681 Dihydrochloride bipolar disorder schizophrenia JNJ37822681 dihydrochloride apomorphine JNJ-37822681 JNJ 37822681 dihydrochloride JNJ37822681 Inhibitor JNJ 37822681 inhibit inhibitor