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JNJ-37822681
🥰Excellent
Catalog No. T27677Cas No. 935776-74-2
Alias JNJ37822681, JNJ 37822681
JNJ-37822681 is a novel, highly selective dopamine D₂ receptor antagonist characterized by a rapid dissociation rate from the dopamine D₂ receptor.
JNJ-37822681
🥰Excellent
Purity: 99.48%
Catalog No. T27677Alias JNJ37822681, JNJ 37822681Cas No. 935776-74-2
JNJ-37822681 is a novel, highly selective dopamine D₂ receptor antagonist characterized by a rapid dissociation rate from the dopamine D₂ receptor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $89 | In Stock | |
| 2 mg | $126 | In Stock | |
| 5 mg | $197 | In Stock | |
| 10 mg | $298 | In Stock | |
| 25 mg | $487 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $212 | In Stock |
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Purity:99.48%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | JNJ-37822681 is a novel, highly selective dopamine D₂ receptor antagonist characterized by a rapid dissociation rate from the dopamine D₂ receptor. |
| Targets&IC50 | D2:0.39 mg/kg(ED50) |
| In vivo | JNJ-37822681 occupied D2 receptors in rat brain at relatively low doses (ED50 = 0.39 mg/kg) and was effective in animal models of psychosis (e.g., inhibition of apomorphine-induced stereotypy or D-amphetamine/phencyclidine-induced hyperlocomotion)[4]. |
| Alias | JNJ37822681, JNJ 37822681 |
| Molecular Weight | 372.34 |
| Formula | C17H17F5N4 |
| Cas No. | 935776-74-2 |
| Smiles | C(C1=CC(F)=C(F)C=C1)N2CCC(NC3=CC=C(C(F)(F)F)N=N3)CC2 |
| Relative Density. | 1.383 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/ml (147.71 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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