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JNJ-37822681 dihydrochloride

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Purity:98.13%

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COA HPLC HNMR

JNJ-37822681 dihydrochloride

Catalog No. T11722Cas No. 2108806-02-4

JNJ-37822681 dihydrochloride is a novel, highly selective dopamine D₂ receptor antagonist characterized by a rapid dissociation rate from the dopamine D₂ receptor. JNJ-37822681 dihydrochloride shows a moderate binding affinity for the dopamine D2L receptor with a Ki of 158 nM.

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

Pack Size	Price	Availability
1 mg	$56	In Stock
5 mg	$116	In Stock
10 mg	$163	In Stock
25 mg	$270	In Stock
1 mL x 10 mM (in DMSO)	$141	In Stock

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Product Introduction

Bioactivity

Description	JNJ-37822681 has potential for the treatment of schizophrenia and bipolar disorder.JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2
Targets&IC50	D2:158 nM(Ki), D2:0.39 mg/kg(ED50)
In vivo	JNJ-37822681 dihydrochloride occupied D2 receptors in rat brain at relatively low doses (ED50 = 0.39 mg/kg) and was effective in animal models of psychosis (e.g., inhibition of apomorphine-induced stereotypy or D-amphetamine/phencyclidine-induced hyperlocomotion)[4].

Chemical Properties

Molecular Weight	445.26
Formula	C17H19Cl2F5N4
Cas No.	2108806-02-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 70 mg/mL (157.21 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2459 mL	11.2294 mL	22.4588 mL	112.2939 mL
5 mM	0.4492 mL	2.2459 mL	4.4918 mL	22.4588 mL
10 mM	0.2246 mL	1.1229 mL	2.2459 mL	11.2294 mL
20 mM	0.1123 mL	0.5615 mL	1.1229 mL	5.6147 mL
50 mM	0.0449 mL	0.2246 mL	0.4492 mL	2.2459 mL
100 mM	0.0225 mL	0.1123 mL	0.2246 mL	1.1229 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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