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LY310762
🥰Excellent
Catalog No. T2688Cas No. 192927-92-7
Alias LY310762 HCl
LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.
LY310762
🥰Excellent
Purity: 99.80%
Catalog No. T2688Alias LY310762 HClCas No. 192927-92-7
LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $29 | In Stock | |
| 10 mg | $43 | In Stock | |
| 25 mg | $88 | In Stock | |
| 50 mg | $142 | In Stock | |
| 100 mg | $229 | In Stock | |
| 200 mg | $347 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock |
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CitedSelect Batch
Purity:99.80%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM. |
| Targets&IC50 | 5-HT1D:249 nM(Ki) |
| In vitro | Following treatment with LY310762, the levels of 5-HT in animals treated with fluoxetine increased from 312±43% to a peak of 683%. In the control group, the 5-HT levels remained constant at 250%. Compared to animals that received a control vehicle injection, systemic administration of 10 mg/kg i.p. LY310762 significantly enhanced the response of 5-HT to 20 mg/kg i.p. fluoxetine. When administered alone, LY310762 notably raised the baseline levels of 5-HT above the vehicle control, achieving a maximum value of 258% compared to the pre-injection control group. |
| In vivo | LY310762 enhances potassium-induced [3H] 5-HT efflux from guinea pig cortical slices, with an EC50 of 30 nM. The maximal enhancement of potassium-induced [3H]5-HT efflux by LY310762 is approximately 40%. LY310762 exhibits a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor. |
| Alias | LY310762 HCl |
| Molecular Weight | 430.94 |
| Formula | C24H27FN2O2·HCl |
| Cas No. | 192927-92-7 |
| Smiles | Cl.CC1(C)C(=O)N(CCN2CCC(CC2)C(=O)c2ccc(F)cc2)c2ccccc12 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 43.1 mg/mL (100 mM) H2O: 4.3 mg/mL (10 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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