Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 64.00 | |
5 mg | In stock | $ 155.00 | |
10 mg | In stock | $ 289.00 | |
25 mg | In stock | $ 537.00 | |
50 mg | In stock | $ 775.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 169.00 |
Description | MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent. |
Targets&IC50 | MDM2:1 nM (IC50) |
In vitro | MD-224 effectively induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells. It achieves an IC50 value of 1.5 nM in inhibition of growth of RS4;11 cells and also low nanomolar IC50 values in a panel of leukemia cell lines. |
In vivo | MD-224 achieves complete and durable tumor regression in vivo in the RS4;11 xenograft tumor model in mice at well-tolerated dose schedules. |
Molecular Weight | 889.8 |
Formula | C48H43Cl2FN6O6 |
CAS No. | 2136247-12-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 150 mg/mL (168.58 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MD-224 2136247-12-4 Apoptosis PROTAC Ubiquitination PROTACs E1/E2/E3 Enzyme Mdm2 inhibit Ubiquitin activating enzyme MD 224 Ubiquitin ligase Inhibitor MD224 MDM-2/p53 cancer E1 activating enzyme Ubiquitin conjugating enzyme E3 ligating enzyme RS4;11 leukemia E2 conjugating enzyme inhibitor