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MD-224

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Purity:100%

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COA HNMR LCMS

MD-224

Catalog No. T11980Cas No. 2136247-12-4

MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.

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Pack Size	Price	Availability
1 mg	$64	In Stock
5 mg	$155	In Stock
10 mg	$289	In Stock
25 mg	$537	In Stock
50 mg	$775	In Stock
1 mL x 10 mM (in DMSO)	$169	In Stock

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Product Introduction

Bioactivity

Description	MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.
In vitro	MD-224 effectively induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells. It achieves an IC50 value of 1.5 nM in inhibition of growth of RS4;11 cells and also low nanomolar IC50 values in a panel of leukemia cell lines.
In vivo	MD-224 achieves complete and durable tumor regression in vivo in the RS4;11 xenograft tumor model in mice at well-tolerated dose schedules.

Chemical Properties

Molecular Weight	889.8
Formula	C48H43Cl2FN6O6
Cas No.	2136247-12-4

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 150 mg/mL (168.58 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1238 mL	5.6192 mL	11.2385 mL	56.1924 mL
5 mM	0.2248 mL	1.1238 mL	2.2477 mL	11.2385 mL
10 mM	0.1124 mL	0.5619 mL	1.1238 mL	5.6192 mL
20 mM	0.0562 mL	0.2810 mL	0.5619 mL	2.8096 mL
50 mM	0.0225 mL	0.1124 mL	0.2248 mL	1.1238 mL
100 mM	0.0112 mL	0.0562 mL	0.1124 mL	0.5619 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc