keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 55.00 | |
5 mg | In stock | $ 99.00 | |
10 mg | In stock | $ 189.00 | |
25 mg | In stock | $ 389.00 | |
50 mg | In stock | $ 658.00 | |
100 mg | In stock | $ 1,098.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 158.00 |
Description | MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM). |
Targets&IC50 | EZH2:120 nM |
In vitro | MS1943 inhibits cell growth (GI50 of 2.2 μM). MS1943 induces cell death in MDA-MB-468 cells. MS1943 effectively reduces EZH2 levels in BT549, HCC70 and MDA-MB-231 TNBC cells, as well as KARPAS-422 and SUDHL8 lymphoma cells and PNT2 non-cancerous prostate cells[1]. |
In vivo | A single i.p. injection of MS1943 at 50 mg/kg body weight achieved a peak plasma concentration (Cmax) of 2.9 μM and resulted in plasma concentrations above its cellular IC50 value for ~2h. A single 150 mg/kg body weight p.o. dose achieved Cmax of 1.1 μM, but plasma concentrations were below the cellular IC50 value.MS1943 suppresses tumor growth[1]. |
Molecular Weight | 718.93 |
Formula | C42H54N8O3 |
CAS No. | 2225938-17-8 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 120 mg/mL (166.91 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MS1943 2225938-17-8 Apoptosis Chromatin/Epigenetic Histone Methyltransferase MS 1943 degrader breast inhibit triple-negative MS-1943 proliferation methyltransferase cancer Inhibitor cytotoxic TNBC inhibitor