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NVP 231

Catalog No. T1933 CAS 362003-83-6

NVP-231 is a potent, specific and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits ceramide binding to CerK.

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NVP 231, CAS 362003-83-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 30.00
10 mg	In stock	$ 48.00
25 mg	In stock	$ 78.00
50 mg	In stock	$ 126.00
100 mg	In stock	$ 207.00
1 mL * 10 mM (in DMSO)	In stock	$ 53.00

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Purity: 98%

Purity: 97.88%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NVP-231 is a potent, specific and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits ceramide binding to CerK.
Targets&IC50	CreK:12±2 nM
Kinase Assay	For deubiquitinase inhibition assays, 19S regulatory particle (5 nM), 26S (5 nM) UCH-L1 (5 nM), UCH-L3 (0.3 nM), USP2CD (5 nM) USP7CD (5 nM) USP8CD (5 nM) or BAP1 (5 nM) is incubated with DMSO or b-AP15 and monitored the cleavage of ubiquitin-AMC (1,000 nM) using a Wallac VICTOR Multilabel counter or a Tecan Infinite M1000 equipped with 380 nm excitation and 460 nm emission filters[1].

Molecular Weight	431.55
Formula	C25H25N3O2S
CAS No.	362003-83-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (127.45 mM)

References and Literature

1. Graf C, et al.Mol Pharmacol. 2008 Oct;74(4):925-32.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Prostate Cancer Compound Library Anti-Pancreatic Cancer Compound Library Kinase Inhibitor Library Oxidation-Reduction Compound Library Osteogenesis Compound Library NO PAINS Compound Library Anti-Aging Compound Library Reprogramming Compound Library Apoptosis Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NVP 231 362003-83-6 Apoptosis MAPK ERK inhibit mcf-7 cancer NVP231 cerk Inhibitor NCI-H358 NVP-231 inhibitor

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