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Ossirene

Catalog No. T6761 CAS 106566-58-9

Synonyms: AS101

Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.

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Ossirene, CAS 106566-58-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
5 mg	In stock	$ 79.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 192.00
50 mg	In stock	$ 293.00
100 mg	In stock	$ 441.00
200 mg	In stock	$ 649.00

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Purity: 98%

Biological Description

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Description	Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.
In vitro	Treatment of caspase-1 (interleukin-1 [IL-1] converting enzyme [ICE]) with AS101 inhibits its enzymatic activity in a dose-dependent manner. Moreover, AS101 treatment causes a significant reduction in the active form of IL-18 and IL-1 in peripheral blood mononuclear cells (PBMC) and in human HaCat keratinocytes. The inhibitory effect of AS101 does not involve nitric oxide (NO) or interferon- (IFN- ), two possible regulators of IL-18 production, and does not occur at the mRNA level. It may exert effects through a posttranscriptional mechanism[1]. AS101 induced SIRT1 expression in a dose dependent manner in three different cell lines, HEK293, HL-60 and Rin-5f. Incubation of HEK293 and HL-60 cell lines with AS101 (0.1-2.5μg/ml) resulted in a dose dependent reduction in PPARγ protein expression relative to the control cells, and the reduction of PPARγ expression is in parallel to increased SIRT1 expression[2].
In vivo	AS101 downregulates IL-18 and IL-1 serum levels in a mouse model of lipopolysaccharide (LPS)-induced sepsis, resulting in increased survival. It has also been shown to be protective against lethal and sublethal effects of irradiation and chemotherapy. In a model of cecal ligation and puncture (CLP)-induced sepsis in mice, AS101 also exerted beneficial effects[1]. AS101 treated rats showed a large increase in SIRT1 protein levels in the liver and kidney extracts of rats treated with AS101. AS101 prevents development of insulin resistance in vivo. AS101 affects SIRT1 related metabolic pathways by changing the insulin levels. AS101 treatment prevents hyperglycemia associated with T2D(type 2 diabetes) and some of the symptoms of the disease in the HFD(high fat diet)+STZ(Streptozotocin) rat model[2].
Cell Research	In vitro, PBMCs were first treated with various concentrations of AS101, and after 1 h SAC (10-3 v/v) was added. After 24 h, supernatants were collected and evaluated for cytokine content. (Only for Reference)

Synonyms	AS101
Molecular Weight	312.05
Formula	C2H4Cl3O2Te·H4N
CAS No.	106566-58-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 198.7 mM

References and Literature

1. Brodsky M, et al. J Interferon Cytokine Res. 2007, 27(6):453-62. 2. Halperin-Sheinfeld M, et al. Aging (Albany NY). 2012, 4(6):436-47.

Citations

1. Wei Wei,Jia Li,Fan Liu, et al. Alteration of intestinal microecology by oral antibiotics promotes oral squamous cell carcinoma development. Molecular Immunology. 2022 Jul 6;149:94-106

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Immunology/Inflammation Compound Library Apoptosis Compound Library Bioactive Compound Library Anti-Cancer Compound Library Protease Inhibitor Library Bioactive Compounds Library Max

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Keywords

Ossirene 106566-58-9 Apoptosis Immunology/Inflammation Proteases/Proteasome Interleukin Caspase IL Receptor RPE NFκB Inhibitor inhibit diseases AS101 immunomodulatory AS-101 autoimmune malignancies tellurium AS 101 IL-6 IL-8 p65 Interleukin Related STAT3 phosphorylation inhibitor

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