Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Palonosetron hydrochloride (RS 25259) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 47.00 | |
50 mg | In stock | $ 55.00 | |
100 mg | In stock | $ 86.00 | |
200 mg | In stock | $ 135.00 |
Description | Palonosetron hydrochloride (RS 25259) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting. |
In vivo | Palonosetron exhibits a longer plasma half-life of approximately 40 hours compared to other antagonists in its class (ondansetron, 4 hours; tropisetron, 7.3 hours; dolasetron, 7.5 hours; ranisetron, 8.9 hours). Additionally, it demonstrates a hundredfold greater binding affinity to the 5-HT3 receptor, with a pKi of 10.5, which is significantly higher than that of granisetron (pKi 8.91), tropisetron (pKi 8.81), ondansetron (pKi 8.39), and dolasetron (pKi 7.6). |
Synonyms | RS 25259 197, Palonosetron HCl, RS 25259 |
Molecular Weight | 332.87 |
Formula | C19H24N2O·HCl |
CAS No. | 135729-62-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 100 mg/mL (300.42 mM), Sonification is recommended.
DMSO: 3.33 mg/mL (10.00 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Palonosetron hydrochloride 135729-62-3 GPCR/G Protein Neuroscience 5-HT Receptor Serotonin Receptor RS-25259 Inhibitor inhibit RS 25259 197 Palonosetron HCl Palonosetron RS 25259 5-hydroxytryptamine Receptor Palonosetron Hydrochloride RS25259 inhibitor