Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Prucalopride Succinate (Resolor Succinate) is a selective, high affinity 5-HT4 receptor agonist, inhibiting human 5-HT(4a) and 5-HT(4b) receptor with Ki value of 2.5 nM and 8 nM, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 40.00 | |
25 mg | In stock | $ 50.00 | |
50 mg | In stock | $ 68.00 | |
100 mg | In stock | $ 115.00 | |
200 mg | In stock | $ 181.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 30.00 |
Description | Prucalopride Succinate (Resolor Succinate) is a selective, high affinity 5-HT4 receptor agonist, inhibiting human 5-HT(4a) and 5-HT(4b) receptor with Ki value of 2.5 nM and 8 nM, respectively. |
Targets&IC50 | 5-HT4B:8 nM(Ki), 5-HT4A:2.5 nM(Ki) |
In vitro | Prucalopride induces contractions in a concentration-dependent manner with pEC50 of 7.5. Prucalopride (1 mM) significantly amplifies the rebound contraction of the guinea-pig proximal colon after electrical field stimulation. Prucalopride induces relaxation of the rat oesophagus preparation of rat oesophagus tunica muscularis mucosae with pEC50 of 7.8, yielding a monophasic concentration–response curve. [1] Prucalopride (0.1 μM) concentration-dependently increases the amplitude of submaximal cholinergic contractions and of acetylcholine release induced by electrical field stimulation in pig gastric circular muscle, and the effect is induced and enhanced IBMX (10 μM). [2] Prucalopride (1 μM) significantly enhances the electrically induced cholinergic contractions in pig descending colon, and the facilitating effect is significantly enhanced by Rolipram. [3] |
In vivo | Prucalopride alters colonic contractile motility patterns in a dose-dependent fashion by stimulating high-amplitude clustered contractions in the proximal colon and by inhibiting contractile activity in the distal colon of fasted dogs. Prucalopride also causes a dose-dependent decrease in the time to the first giant migrating contraction (GMC); at higher doses of prucalopride, the first GMC generally occurres within the first half-hour after treatment. [4] |
Synonyms | R-108512, Resolor Succinate |
Molecular Weight | 485.96 |
Formula | C18H26ClN3O3·C4H6O4 |
CAS No. | 179474-85-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: 89 mg/mL (183.1 mM)
DMSO: 90 mg/mL (185.2 mM)
You can also refer to dose conversion for different animals. More
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Prucalopride Succinate 179474-85-2 GPCR/G Protein Neuroscience 5-HT Receptor inhibit Inhibitor Serotonin Receptor R-108512 5-hydroxytryptamine Receptor R108512 Prucalopride R 108512 Resolor Succinate inhibitor