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RRX-001

Catalog No. T7400   CAS 925206-65-1

RRx-001 is a potent inhibitor ofglucose 6-phosphate dehydrogenase(G6PD) and with potent antimalarial activity

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RRX-001 Chemical Structure
RRX-001, CAS 925206-65-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 48.00
2 mg In stock $ 70.00
5 mg In stock $ 117.00
10 mg In stock $ 155.00
25 mg In stock $ 293.00
50 mg In stock $ 513.00
100 mg In stock $ 748.00
500 mg In stock $ 1,560.00
1 mL * 10 mM (in DMSO) In stock $ 129.00
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Purity: 98.39%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description RRx-001 is a potent inhibitor ofglucose 6-phosphate dehydrogenase(G6PD) and with potent antimalarial activity
In vitro RRx-001 inhibited the growth of colon cancer cells (HCT 116) and decreased levels of the DNA methyltransferases DNMT1 and DNMT3a in a time and dose-dependent manner. Treatment of HCT 116 cells with 0.5 μM RRx-001 for 24 h significantly increased transcripts of interferon (IFN)-responsive genes and this induction was sustained for up to 4 weeks after transient exposure to RRx-001. RRx-001 increased secretion of type I and III IFNs by HCT 116 cells, and these IFNs were confirmed to be bioactive. Transcription of endogenous retrovirus ERV-Fc2 and LTRs from the ERV-L family (MLT2B4 and MLT1C49) was induced by RRx-001[1].
Molecular Weight 268.02
Formula C5H6BrN3O5
CAS No. 925206-65-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (373.11 mM)

TargetMolReferences and Literature

1. Zhao H , Ning S , Nolley R , et al. The immunomodulatory anticancer agent, RRx-001, induces an interferon response through epigenetic induction of viral mimicry[J]. Clinical Epigenetics, 2017, 9(1):4. 2. Oronsky B , Paulmurugan R , Foygel K , et al. RRx-001: a systemically non-toxic M2-to-M1 macrophage stimulating and prosensitizing agent in Phase II clinical trials[J]. Expert Opinion on Investigational Drugs, 2017, 26(1):109-119.

TargetMolCitations

1. Gong M, Huang Y, Feng H, et al.A nanodrug combining CD47 and sonodynamic therapy efficiently inhibits osteosarcoma deterioration.Journal of Controlled Release.2023, 355: 68-84.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Parasitic Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Aging Compound Library Ferroptosis Compound Library NO PAINS Compound Library Preclinical Compound Library Immunology/Inflammation Compound Library Bioactive Compound Library

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Keywords

RRX-001 925206-65-1 Apoptosis Metabolism Microbiology/Virology Dehydrogenase Parasite RRX 001 RRx-001 Inhibitor RRX001 inhibit inhibitor

 

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