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Rhosin hydrochloride

Catalog No. T16745 CAS 1281870-42-5

Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydrochloride does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin hydrochloride causes cell apoptosis.

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Rhosin hydrochloride, CAS 1281870-42-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 162.00
2 mg	In stock	$ 229.00
5 mg	In stock	$ 347.00
10 mg	In stock	$ 497.00
25 mg	In stock	$ 793.00
50 mg	In stock	$ 1,080.00
100 mg	In stock	$ 1,450.00
1 mL * 10 mM (in DMSO)	In stock	$ 382.00

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Purity: 98.92%

Purity: 97.33%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydrochloride does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin hydrochloride causes cell apoptosis.
Targets&IC50	RhoA:(kd)0.4 uM
In vitro	Rhosin hydrochloride causes decreased size and reduced number of mammospheres in MCF7 cells. Rhosin hydrochloride dose-dependently reduces RhoA and p-MLC1 activities of MCF7 cell-derived mammospheres (EC50: ~30-50 μM) [1].

Molecular Weight	431.318
Formula	C20H20Cl2N6O
CAS No.	1281870-42-5

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (253.25 mM), Sonification is recommended.

References and Literature

1. Shang X, et al. Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases. Chem Biol. 2012 Jun 22;19(6):699-710. 2. Shang X, et al. Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3155-60.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library GPCR Compound Library Inhibitor Library Anti-Ovarian Cancer Compound Library Anti-Cancer Compound Library Cytoskeletal Signaling Pathway Compound Library Anti-Obesity Compound Library Bioactive Compounds Library Max Neural Regeneration Compound Library Anti-Prostate Cancer Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Rhosin hydrochloride 1281870-42-5 Apoptosis Cell Cycle/Checkpoint GPCR/G Protein MAPK Rho Ras plasticity D1-MSN MCF7 hyperexcitability stress Rhosin selective inhibit cells Inhibitor resiliency Rhosin Hydrochloride inhibitor

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