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SCH-23390 hydrochloride
Catalog No. T4369Cas No. 125941-87-9
Alias R-(+)-SCH23390 hydrochloride
SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) is an effective dopamine receptor antagonist, with high affinity for the D1 (Ki=0.2 nM) and D5 (Ki=0.3 nM) receptors.
SCH-23390 hydrochloride
Catalog No. T4369Alias R-(+)-SCH23390 hydrochlorideCas No. 125941-87-9
SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) is an effective dopamine receptor antagonist, with high affinity for the D1 (Ki=0.2 nM) and D5 (Ki=0.3 nM) receptors.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $33 | In Stock | |
| 2 mg | $46 | In Stock | |
| 5 mg | $71 | In Stock | |
| 10 mg | $98 | In Stock | |
| 25 mg | $205 | In Stock | |
| 50 mg | $389 | In Stock | |
| 100 mg | $579 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $71 | In Stock |
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CitedSelect Batch
Purity:99.51%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) is an effective dopamine receptor antagonist, with high affinity for the D1 (Ki=0.2 nM) and D5 (Ki=0.3 nM) receptors. |
| Targets&IC50 | D5:0.3 nM, D1:0.2 nM |
| In vitro | SCH23390 blocks endogenous GIRK currents induced by either somatostatin or D3 dopamine receptors in AtT-20 cells (IC50=268 nM).SCH 23390 also shows high affinity (Ki=9.3 nM) at h5-HT2C sites. |
| In vivo | In the rat, the repeated administration of SCH 23390 (0.05 mg/kg s.c., thrice daily for 21 days) enhances the steady-state density of dopamine D1 receptors in the striatum (+30%) and substantia nigra (+24%). |
| Animal Research | Rats are injected with SCH 23390(0, 1, or 10 μg/kg i.p.). |
| Alias | R-(+)-SCH23390 hydrochloride |
| Molecular Weight | 324.24 |
| Formula | C17H19Cl2NO |
| Cas No. | 125941-87-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 25 mg/mL (77.10 mM), Sonication is recommended.  DMSO: 50 mg/mL (154.21 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
5-hydroxytryptamine ReceptorSCH 23390 hydrochlorideSCH23390SCH 23390InhibitorepileptiformconstrictioninhibitR-SCH23390 HydrochlorideDA1-likeductus5‐HT1CGIRKR-SCH-23390 Hydrochloride5-HT ReceptorSCH-23390 HydrochlorideSCH23390 HydrochlorideR-SCH 23390 HydrochlorideenantioselectiveD5-receptorDopamine ReceptorSCH 23390 Hydrochloride5‐HT2KcsASCH-23390Serotonin ReceptorSCH23390 hydrochlorideneurologicalPotassium Channel
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