Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) is an effective dopamine receptor antagonist, and for the D1(Ki=0.2 nM) and D5(Ki=0.3 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 33.00 | |
2 mg | In stock | $ 46.00 | |
5 mg | In stock | $ 71.00 | |
10 mg | In stock | $ 98.00 | |
25 mg | In stock | $ 205.00 | |
50 mg | In stock | $ 389.00 | |
100 mg | In stock | $ 579.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 71.00 |
Description | SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) is an effective dopamine receptor antagonist, and for the D1(Ki=0.2 nM) and D5(Ki=0.3 nM). |
Targets&IC50 | D5:0.3 nM, D1:0.2 nM |
In vitro | SCH23390 blocks endogenous GIRK currents induced by either somatostatin or D3 dopamine receptors in AtT-20 cells (IC50=268 nM).SCH 23390 also shows high affinity (Ki=9.3 nM) at h5-HT2C sites. |
In vivo | In the rat, the repeated administration of SCH 23390 (0.05 mg/kg s.c., thrice daily for 21 days) enhances the steady-state density of dopamine D1 receptors in the striatum (+30%) and substantia nigra (+24%). |
Animal Research | Rats are injected with SCH 23390(0, 1, or 10 μg/kg i.p.). |
Synonyms | R-(+)-SCH23390 hydrochloride |
Molecular Weight | 324.24 |
Formula | C17H19Cl2NO |
CAS No. | 125941-87-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (154.21 mM)
You can also refer to dose conversion for different animals. More
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SCH-23390 hydrochloride 125941-87-9 GPCR/G Protein Membrane transporter/Ion channel Neuroscience 5-HT Receptor Dopamine Receptor Potassium Channel 5-hydroxytryptamine Receptor SCH 23390 hydrochloride SCH23390 R-(+)-SCH23390 hydrochloride SCH 23390 Inhibitor epileptiform constriction inhibit R-SCH23390 Hydrochloride DA1-like ductus 5‐HT1C GIRK R-SCH-23390 Hydrochloride SCH-23390 Hydrochloride SCH23390 Hydrochloride R-SCH 23390 Hydrochloride enantioselective D5-receptor SCH 23390 Hydrochloride 5‐HT2 KcsA SCH-23390 Serotonin Receptor SCH23390 hydrochloride neurological inhibitor