r-sch-23390 hydrochloride

Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor. Duvelisib (R enantiomer) hydrochloride is the less active enantiomer of Duvelisib.

(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).

(S,R,S)-AHPC-Me-C10-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating a VHL ligand and a linker.

(S,R,S)-AHPC-PEG2-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 6) is a synthesized E3 ligase ligand-linker conjugate that includes the (S,R,S)-AHPC based VHL ligand and a 2-unit PEG linker used in the synthesis of PROTAC.

(S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) is a synthesized E3 ligase ligand-linker conjugate comprising the (S,R,S)-AHPC-based VHL ligand and a linker.

(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is utilized in the synthesis of ARV-771, a potent BET protein degrader. It selectively degrades BET protein in castration-resistant cells with a DC50 <1 nM. Recognized as VHL ligand 2 hydrochloride, it serves as the VHL ligand from (S,R,S)-AHPC for recruiting von Hippel-Lindau (VHL) protein.

(R)-Viloxazine Hydrochloride is the R-isomer of Viloxazine, a selective norepinephrine reuptake inhibitor (NRI) used as an antidepressant.

(S,R,S)-AHPC-PEG3-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 5) is an E3 ligase ligand-linker conjugate that integrates the (S,R,S)-AHPC-based VHL ligand with a 3-unit PEG linker.

SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) is an effective dopamine receptor antagonist, with high affinity for the D1 (Ki=0.2 nM) and D5 (Ki=0.3 nM) receptors.

(R)-Preclamol hydrochloride ((+)-3-PPP hydrochloride), the R-enantiomer of Preclamol hydrochloride, acts as a DA agonist by stimulating both autoreceptors and postsynaptic receptors [1][2].

(S, R, S)-AHPC-C6-NH2 hydrochloride (also known as VH032-C6-NH2 hydrochloride) is a synthetic E3 ligase ligand-linker conjugate. It combines the VH032-based VHL ligand with a linker designed for AKT PROTAC degrader applications.

Arbaclofen hydrochloride, a Gamma-Aminobutyric Acid derivative, is a specific agonist of GABA-B receptors, it is used to treat spasticity, especially that due to spinal cord damage. It acts at spinal and supraspinal sites, generally reduces excitatory tra

R 59-022 hydrochloride (DKGI-I hydrochloride) is a 5-HT Receptor antagonist that activates protein kinase C (PKC).R 59-022 hydrochloride is a DGK inhibitor (IC50:2.8 µM) that inhibits the phosphorylation of OAG to OAPA.R 59-022 enhances thrombin-induced triglyceride production in platelets and inhibits the production of phosphatidic acid in neutrophils. R 59-022 enhances thrombin-induced diglyceride production in platelets and inhibits phosphatidic acid production in neutrophils.

DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent and specific inhibitor of glutamylcysteine synthetase biosynthesis.

SCH 50911 hydrochloride is a selective, orally-active and competitive antagonist of γ-Aminobutyric acid B GABA(B) receptor(IC50 : 1.1 μM).

(R)-Duloxetine Hydrochloride is a napthalenyloxy-substituted amine used in binding studies of human serum albumin along with (S)-Duloxetine. Unlike its enantiomer, it is not a very effective dual serotonin and norepinephrine reuptake inhibitor (SNRI).

(R)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride is a useful organic compound for research related to life sciences and the catalog number is T64535.

(R)-2-Aminobutanamide hydrochloride is a useful organic compound for research related to life sciences and the catalog number is T67001.

(R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is an inhibitor of P-Glycoprotein.

(R)-SCH 42495, the less active enantiomer of SCH 42495, is an orally active inhibitor of neutral metalloendopeptidase (NEP) with antihypertensive effects.

(R)-Benzyl 2-amino-3-(3-(methylsulfonyl)phenyl)propanoate hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T67333 and the CAS number is 2049127-88-8.

(R,R)-Palonosetron Hydrochloride, the active enantiomer of Palonosetron, is a selective 5-HT3 receptor antagonist used primarily for the prevention of chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).

(R)-1-Amino-3-chloro-2-propanol hydrochloride is a biochemical.

(R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist with a high affinity for β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively.

Afurolol hydrochloride, (R)-, is a beta blocker.

5-HT2 receptor antagonist

(R)-Azelastine hydrochloride is an antihistamine which has been shown to down-regulate H1R, M1R and M3R levels. This compound has also been shown to inhibit HNEpC proliferation.

(R)-Lercanidipine hydrochloride is the R-enantiomer of Lercanidipine and functions as a calcium channel blocker.

(R)-Methyl 2-amino-3-phenylpropanoate hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65085 and the CAS number is 13033-84-6.

(R)-tert-Butyl 2-amino-4-methylpentanoate hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66824 and the CAS number is 13081-32-8.

(R)-Methyl 2-amino-3-(4-chlorophenyl)propanoate hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65936 and the CAS number is 33965-47-8.

(R)-Gyramide A hydrochloride is a bacterial DNA gyrase inhibitor that disrupts superhelical activity (IC50: 875 μM) and exhibits antibacterial activity against Pseudomonas aeruginosa E. coli with MIC values of 10-80 μM, without affecting the closely related enzyme topoisomerase IV.

(R)-Tetrahydropapaverine hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66037 and the CAS number is 54417-53-7.

(R)-2-((4-Aminophenethyl)amino)-1-phenylethanol hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66549 and the CAS number is 521284-22-0.

(R)-Methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65096 and the CAS number is 212838-70-5.

(S, R, S)-AHPC-PEG4-NH2 hydrochloride is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker, incorporating the VHL ligand based on (S, R, S)-AHPC, and a 4-unit PEG linker, which are specifically designed for use in PROTAC technology.

(R)-DOI hydrochloride is a 5-HT2 receptor agonist, inhibiting TNF-α-mediated proinflammatory signaling cascades and inflammation via 5-HT2A receptor activation and preventing the development of, and inflammation associated with, acute allergic asthma.

L-Buthionine-(S,R)-sulfoximine hydrochloride is a potent, cell-permeable, fast-acting, irreversible inhibitor of G-glutamylcysteine synthetase (γ-GCS) that depletes cellular glutathione levels. It has IC50s of 1.9 μM, 8.6 μM, and 29 μM in melanoma, breast, and ovarian tumor specimens, respectively [1] [2].

R-(-)-Tretoquinol Hydrochloride-d9 is a deuterated compound of R-(-)-Tretoquinol Hydrochloride.

(R)-Methyl 2-amino-2-cyclohexylacetate hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66149 and the CAS number is 14328-64-4.

(R)-tert-Butyl 2-amino-2-phenylacetate hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T67246 and the CAS number is 256478-95-2.

(R)-V-0219 hydrochloride, an enantiomer of V-0219, functions as an orally active positive allosteric modulator (PAM) of the GLP-1 Receptor (GLP-1R). It induces calcium fluxes in HEK cells expressing hGLP-1R [1], highlighting its biochemical activity and potential therapeutic applications.

High affinity corticotropin releasing factor receptor1 (CRF1) antagonist (Ki = 3.5 nM). Reduces stress-induced elevations of plasma ACTH. Anxiolytic and antidepressant in vivo. Orally bioavailable. Chen and Grigoriadis (2005) NBI 30775 (R121919), an orally active antagonist of the corticotropin-releasing factor (CRF) type-1 receptor for the treatment of anxiety and depression. Drug Dev.Res. 65 216 |Jutkiewicz et al (2005) The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats. Psychopharmacology (Berl). 180 215 PMID:15696320 |Gutman et al (2003) The corticotropin-releasing factor1 receptor antagonist R121919 attenuates the behavioral and endocrine responses to stress. J.Pharmacol.Exp.Ther. 304 874 PMID:12538845 |Heinrichs et al (2002) Brain penetrance, receptor occupancy and antistress in vivo efficacy of a small molecule cortico. releasing factor type I receptor selective antagonist. Neuropsychopharmacology 27 194 PMID:12093593

(R)-Ethyl 2-amino-2-phenylacetate hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65809 and the CAS number is 17609-48-2.

(R)-lercanidipine D3 hydrochloride is a deuterium labeled (R)-Lercanidipine hydrochloride. (R)-Lercanidipine D3 (hydrochloride) is a calcium channel blocker.

AR-R17779 hydrochloride is a potent, selective full agonist of the nAChR, demonstrating K i values of 92 nM for the α7 subtype and 16,000 nM for the α4β2 subtype. It is noted for its ability to enhance learning and memory in rats, suggesting potential therapeutic applications. Additionally, this compound exhibits anxiolytic properties and can mitigate inflammation by activating anti-inflammatory cholinergic (vagal) pathways [1] [2] [4].

(R)-SCH-23982 HCl is a [125I]-(R)-SCH-23982 precursor and a D1 antagonist.

(S,R,S)-AHPC-CO-C9-NH2 (hydrochloride) serves as a von Hippel-Lindau (VHL) amino building block essential for the synthesis of E3 ligase ligands, which are necessary for the development of PROTACs.'