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Ximelagatran

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Purity:98.09%

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COA HPLC HNMR

Ximelagatran

Catalog No. T17265Cas No. 192939-46-1

Ximelagatran (H 376-95), a direct thrombin inhibitor, can be taken orally and acts solely by inhibiting the actions of thrombin. Ximelagatran is converted to the active agent melagatran in vivo.

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Pack Size	Price	Availability
1 mg	$60	In Stock
2 mg	$81	In Stock
5 mg	$123	In Stock
10 mg	$213	In Stock
25 mg	$372	In Stock
50 mg	$455	In Stock
100 mg	$629	In Stock
1 mL x 10 mM (in DMSO)	$138	In Stock

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Product Introduction

Bioactivity

Description	Ximelagatran (H 376-95), a direct thrombin inhibitor, can be taken orally and acts solely by inhibiting the actions of thrombin. Ximelagatran is converted to the active agent melagatran in vivo.
In vitro	Ximelagatran, an orally administered direct thrombin inhibitor, is currently being developed for both the prophylaxis and treatment of thromboembolism. Once ingested, it is rapidly absorbed and converted into its active metabolite, Melagatran, which acts as a reversible, active-site inhibitor targeting both free and clot-bound thrombin, showcasing stable and reproducible pharmacokinetic properties. Initial research indicates Ximelagatran's promising efficacy and safety profile in preventing venous thromboembolism following total knee or hip replacement surgeries[1].
Alias	EXANTA, H 376-95, H37695, H 376/95, H-37695, H 37695

Chemical Properties

Molecular Weight	473.57
Formula	C24H35N5O5
Cas No.	192939-46-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (116.14 mM)

H2O: Insoluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1116 mL	10.5581 mL	21.1162 mL	105.5810 mL
5 mM	0.4223 mL	2.1116 mL	4.2232 mL	21.1162 mL
10 mM	0.2112 mL	1.0558 mL	2.1116 mL	10.5581 mL
20 mM	0.1056 mL	0.5279 mL	1.0558 mL	5.2791 mL
50 mM	0.0422 mL	0.2112 mL	0.4223 mL	2.1116 mL
100 mM	0.0211 mL	0.1056 mL	0.2112 mL	1.0558 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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