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Ximelagatran

Catalog No. T17265 CAS 192939-46-1

Synonyms: EXANTA, H 376-95, H37695, H 376/95, H-37695, H 37695

Ximelagatran (H 376-95), a direct thrombin inhibitor, can be taken orally and acts solely by inhibiting the actions of thrombin. Ximelagatran is converted to the active agent melagatran in vivo.

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Ximelagatran, CAS 192939-46-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 61.00
5 mg	In stock	$ 124.00
10 mg	In stock	$ 216.00
25 mg	In stock	$ 497.00
50 mg	In stock	$ 559.00
100 mg	In stock	$ 797.00
200 mg	In stock	$ 1,120.00
1 mL * 10 mM (in DMSO)	In stock	$ 141.00

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Purity: 98.09%

Purity: 95.48%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Ximelagatran (H 376-95), a direct thrombin inhibitor, can be taken orally and acts solely by inhibiting the actions of thrombin. Ximelagatran is converted to the active agent melagatran in vivo.

In vitro

Ximelagatran, an orally administered direct thrombin inhibitor, is currently being developed for both the prophylaxis and treatment of thromboembolism. Once ingested, it is rapidly absorbed and converted into its active metabolite, Melagatran, which acts as a reversible, active-site inhibitor targeting both free and clot-bound thrombin, showcasing stable and reproducible pharmacokinetic properties. Initial research indicates Ximelagatran's promising efficacy and safety profile in preventing venous thromboembolism following total knee or hip replacement surgeries[1].

Synonyms	EXANTA, H 376-95, H37695, H 376/95, H-37695, H 37695
Molecular Weight	473.57
Formula	C24H35N5O5
CAS No.	192939-46-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (116.14 mM)

H2O: Insoluble

References and Literature

1. Francis CW, et al. Comparison of ximelagatran with warfarin for the prevention of venous thromboembolism after total knee replacement. N Engl J Med. 2003 Oct 30;349(18):1703-12. 2. Lazo-Langner A, Rodger MA, Wells PS. Lessons from ximelagatran: issues for future studies evaluating new oral direct thrombin inhibitors for venous thromboembolism prophylaxis in orthopedic surgery. Clin Appl Thromb Hemost. 2009 May-Jun;15(3):316-26. doi: 10.1177/1076029608326166. Review. PubMed PMID: 19028773. 3. Testa L, Bhindi R, Agostoni P, Abbate A, Zoccai GG, van Gaal WJ. The direct thrombin inhibitor ximelagatran/melagatran: a systematic review on clinical applications and an evidence based assessment of risk benefit profile. Expert Opin Drug Saf. 2007 Jul;6(4):397-406. Review. PubMed PMID: 17688383. 4. Koscielny J, Kiesewetter H, Jörg I, Harenberg J. Ximelagatran for treatment and prophylaxis of recurrent events in deep vein thrombosis. Clin Appl Thromb Hemost. 2007 Jul;13(3):299-307. Review. PubMed PMID: 17636192. 5. Keisu M, Andersson TB. Drug-induced liver injury in humans: the case of ximelagatran. Handb Exp Pharmacol. 2010;(196):407-18. doi: 10.1007/978-3-642-00663-0_13. Review. PubMed PMID: 20020269.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Orally Active Compound Library Anti-Cardiovascular Disease Compound Library Protease Inhibitor Library ReFRAME Related Library Bioactive Compound Library Drug-induced Liver Injury (DILI) Compound Library Bioactive Compounds Library Max Clinical Compound Library

Related Products

Related compounds with same targets

Melagatran Rivaroxaban Thrombin (MW 37kDa) Menadione p-Hydroxycinnamic acid Ozagrel Dabigatran Heparin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Ximelagatran 192939-46-1 Proteases/Proteasome Thrombin EXANTA H 376-95 Inhibitor inhibit H37695 H 376/95 H-37695 H 37695 inhibitor

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