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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $133 | In Stock | |
5 mg | $302 | In Stock | |
10 mg | $453 | In Stock | |
25 mg | $747 | In Stock | |
50 mg | $1,050 | In Stock | |
100 mg | $1,420 | In Stock | |
1 mL x 10 mM (in DMSO) | $297 | In Stock |
Description | A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties |
In vitro | A-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs, with acceptable pharmacokinetic properties and excellent distribution to the central nervous system (CNS).?In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation.?A-582941 enhanced cognitive performance in behavioral models that capture domains of working memory, short-term recognition memory, memory consolidation, and sensory gating deficit.?A-582941 exhibited a benign secondary pharmacodynamic and tolerability profile as assessed in a battery of assays of cardiovascular, gastrointestinal, and CNS function[1]. |
Molecular Weight | 316.83 |
Formula | C17H21ClN4 |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 12 mg/mL (37.88 mM) ![]() | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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