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Asenapine

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Purity:99.16%

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COA HPLC LCMS HNMR

Asenapine

Catalog No. T21360Cas No. 65576-45-6

Asenapine (Org 5222) is a 5-HT receptor, adrenergic receptor, dopamine receptor, and histamine receptor antagonist with antipsychotic effects that is used to treat schizophrenia and manic or mixed episodes associated with bipolar 1 disorder.CAS 번호721483-46-5

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Pack Size	Price	Availability
1 mg	$32	In Stock
5 mg	$72	In Stock
10 mg	$98	In Stock
25 mg	$168	In Stock
50 mg	$247	In Stock
100 mg	$365	In Stock
1 mL x 10 mM (in DMSO)	$80	In Stock

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Product Introduction

Bioactivity

Description	Asenapine (Org 5222) is a 5-HT receptor, adrenergic receptor, dopamine receptor, and histamine receptor antagonist with antipsychotic effects that is used to treat schizophrenia and manic or mixed episodes associated with bipolar 1 disorder.CAS 번호721483-46-5
Targets&IC50	5-HT1A receptor:8.6 (pKi), 5-HT2A receptor:10.2 (pKi), 5-HT2B receptor:9.8 (pKi), 5-HT1B receptor:8.4 (pKi)
In vitro	In comparison with the antipsychotics, asenapine showed high affinity and a different rank order of binding affinities (pKi) for serotonin receptors (5-HT1A [8.6], 5-HT1B [8.4], 5-HT2A [10.2], 5-HT2B [9.8], 5-HT2C [10.5], 5-HT5 [8.8], 5-HT6 [9.6] and 5-HT7 [9.9]), adrenoceptors (alpha1 [8.9], alpha2A [8.9], alpha2B [9.5] and alpha2C [8.9]), dopamine receptors (D1 [8.9], D2 [8.9], D3 [9.4] and D4 [9.0]) and histamine receptors (H1 [9.0] and H2 [8.2])[2].
In vivo	Asenapine (0.05-0.2 mg/kg, s.c.) induced a dose-dependent suppression of CAR (no escape failures recorded) and did not induce catalepsy. Additionally, it increased dopamine efflux in both the medial prefrontal cortex (mPFC) and the nucleus accumbens (NAc)[2].
Alias	Org 5222, HSDB 8061, ME2136

Chemical Properties

Molecular Weight	285.77
Formula	C17H16ClNO
Cas No.	65576-45-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: Insoluble

DMSO: 80 mg/mL (279.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4993 mL	17.4966 mL	34.9932 mL	174.9659 mL
5 mM	0.6999 mL	3.4993 mL	6.9986 mL	34.9932 mL
10 mM	0.3499 mL	1.7497 mL	3.4993 mL	17.4966 mL
20 mM	0.1750 mL	0.8748 mL	1.7497 mL	8.7483 mL
50 mM	0.0700 mL	0.3499 mL	0.6999 mL	3.4993 mL
100 mM	0.0350 mL	0.1750 mL	0.3499 mL	1.7497 mL

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