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Azelastine hydrochloride

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Purity:100%

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COA HNMR LCMS

Azelastine hydrochloride

Catalog No. T0211LCas No. 79307-93-0

Azelastine hydrochloride (Astelin) is a phthalazinone derivative with antihistaminergic activity.

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Pack Size	Price	Availability	Quantity
50 mg	$30	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock

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Product Introduction

Bioactivity

Description	Azelastine hydrochloride (Astelin) is a phthalazinone derivative with antihistaminergic activity.
In vivo	In the rat basophilic leukemia RBL-2H3 cell line, Azelastine inhibited antigen (Ag)-induced TNF-alpha release (IC50=25.7 mM) and ionomycin-induced TNF-alpha release (IC50=1.66 mM). In mouse peritoneal macrophages, Azelastine suppressed inducible nitric oxide synthase (iNOS) mRNA expression and nitric oxide (NO) production. In normal human mast cells, Azelastine inhibited the secretion of IL-6, TNF-alpha, and IL-8, and the activation of NF-κB, as well as intracellular calcium levels. In human gingival fibroblasts, Azelastine dose-dependently inhibited DNA and protein synthesis.
Alias	Optivar, Azelastine HCl, Allergodil, Astelin

Chemical Properties

Molecular Weight	418.36
Formula	C22H24ClN3O·HCl
Cas No.	79307-93-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 84 mg/mL (200.78 mM)

H2O: 35 mg/mL (83.66 mM)

Ethanol: 57 mg/mL(136.2 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.3903 mL	11.9514 mL	23.9029 mL	119.5143 mL
5 mM	0.4781 mL	2.3903 mL	4.7806 mL	23.9029 mL
10 mM	0.2390 mL	1.1951 mL	2.3903 mL	11.9514 mL
20 mM	0.1195 mL	0.5976 mL	1.1951 mL	5.9757 mL
50 mM	0.0478 mL	0.2390 mL	0.4781 mL	2.3903 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0239 mL	0.1195 mL	0.2390 mL	1.1951 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc