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Azelastine hydrochloride
🥰Excellent
Catalog No. T0211LCas No. 79307-93-0
Alias Optivar, Azelastine HCl, Astelin, Allergodil
Azelastine hydrochloride (Astelin) is a phthalazinone derivative with antihistaminergic activity.
Azelastine hydrochloride
🥰Excellent
Purity: 100%
Catalog No. T0211LAlias Optivar, Azelastine HCl, Astelin, AllergodilCas No. 79307-93-0
Azelastine hydrochloride (Astelin) is a phthalazinone derivative with antihistaminergic activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $30 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $45 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Azelastine hydrochloride (Astelin) is a phthalazinone derivative with antihistaminergic activity. |
| In vivo | In the rat basophilic leukemia RBL-2H3 cell line, Azelastine inhibited antigen (Ag)-induced TNF-alpha release (IC50=25.7 mM) and ionomycin-induced TNF-alpha release (IC50=1.66 mM). In mouse peritoneal macrophages, Azelastine suppressed inducible nitric oxide synthase (iNOS) mRNA expression and nitric oxide (NO) production. In normal human mast cells, Azelastine inhibited the secretion of IL-6, TNF-alpha, and IL-8, and the activation of NF-κB, as well as intracellular calcium levels. In human gingival fibroblasts, Azelastine dose-dependently inhibited DNA and protein synthesis. |
| Alias | Optivar, Azelastine HCl, Astelin, Allergodil |
| Molecular Weight | 418.36 |
| Formula | C22H24ClN3O·HCl |
| Cas No. | 79307-93-0 |
| Smiles | Cl.CN1CCCC(CC1)n1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O |
| Relative Density. | 1.25 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 84 mg/mL (200.78 mM) H2O: 35 mg/mL (83.66 mM) Ethanol: 57 mg/mL (136.2 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/Ethanol/DMSO
Ethanol/DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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