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Branaplam
🥰Excellent
Catalog No. T4641Cas No. 1562338-42-4
Alias NVS-SM1, LMI 070
Branaplam (LMI 070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator.
Branaplam
🥰Excellent
Purity: 99.4%
Catalog No. T4641Alias NVS-SM1, LMI 070Cas No. 1562338-42-4
Branaplam (LMI 070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $42 | In Stock | |
| 2 mg | $58 | In Stock | |
| 5 mg | $98 | In Stock | |
| 10 mg | $153 | In Stock | |
| 25 mg | $245 | In Stock | |
| 50 mg | $368 | In Stock | |
| 100 mg | $547 | In Stock | |
| 500 mg | $1,190 | In Stock |
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Purity:99.4%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Branaplam (LMI 070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator. |
| Targets&IC50 | ERG (human):6.3 μM (EC50), SMN:20 nM (IC50) |
| In vivo | To evaluate the efficacy of NVS-SM1, we used the SMNΔ7 mouse model, which displays a severe phenotype. In the specific colony used for this study, death typically occurs before postnatal day 15. We were pleased to observe that, in addition to a dose-dependent elevation of SMN protein in the brain, oral administration of NVS-SM1 improved body weight and extended lifespan, with 50% of the animals in the 1 mg per kg body weight group and 62% of animals in the 3 mg per kg body weight group showing increased survival. |
| Alias | NVS-SM1, LMI 070 |
| Molecular Weight | 393.48 |
| Formula | C22H27N5O2 |
| Cas No. | 1562338-42-4 |
| Smiles | CC1(C)CC(CC(C)(C)N1)Oc1ccc(nn1)-c1ccc(cc1O)-c1cn[nH]c1 |
| Relative Density. | 1.171 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 3.8 mg/mL (9.6 mM), Sonication and heating are recommended.  | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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