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Ecopipam

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Purity:98.5%

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COA HPLC HNMR

Ecopipam

Catalog No. T31602Cas No. 112108-01-7

Ecopipam (UNII-0X748O646K) is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam can be used for the research of schizophrenia and obesity.

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Pack Size	Price	Availability
1 mg	$195	In Stock
2 mg	$293	In Stock
5 mg	$447	In Stock
10 mg	$659	In Stock
25 mg	$987	In Stock
50 mg	$1,380	In Stock

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Product Introduction

Bioactivity

Description	Ecopipam (UNII-0X748O646K) is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam can be used for the research of schizophrenia and obesity.
In vitro	Ecopipam (2 μM) completely abolishes the proconvulsive effect of Dopamine (10 μM) in isolated corticohippocampal formation[2].
In vivo	Ecopipam (0.003-0.3 mg/kg; a single s.c.) abolishes Nicotine-induced enhancement of a sensory reinforcer in adult rats[3]. Ecopipam (10, mg/kg, oral administration) antagonizes Apomorphine-induced stereotypy in rats[4]. Ecopipam (5 and 10 μM, perfusion, 1 μL/min) reversibly and dose-dependently decreases acetylcholine release in the rat striatum[5].
Alias	Sch-39166, UNII-0X748O646K, Sch 39166

Chemical Properties

Molecular Weight	313.82
Formula	C19H20ClNO
Cas No.	112108-01-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (191.19 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1865 mL	15.9327 mL	31.8654 mL	159.3270 mL
5 mM	0.6373 mL	3.1865 mL	6.3731 mL	31.8654 mL
10 mM	0.3187 mL	1.5933 mL	3.1865 mL	15.9327 mL
20 mM	0.1593 mL	0.7966 mL	1.5933 mL	7.9664 mL
50 mM	0.0637 mL	0.3187 mL	0.6373 mL	3.1865 mL
100 mM	0.0319 mL	0.1593 mL	0.3187 mL	1.5933 mL

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