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Fantofarone

🥰Excellent
Catalog No. T4669Cas No. 114432-13-2
Alias SR 33557

Fantofarone (SR 33557) is a highly potent antagonist of Calcium Channel.

Fantofarone

Fantofarone

🥰Excellent
Purity: 98.36%
Catalog No. T4669Alias SR 33557Cas No. 114432-13-2
Fantofarone (SR 33557) is a highly potent antagonist of Calcium Channel.
Pack SizePriceAvailabilityQuantity
1 mg$31In Stock
5 mg$72In Stock
10 mg$122In Stock
25 mg$247In Stock
50 mg$409In Stock
100 mg$531In Stock
1 mL x 10 mM (in DMSO)$88In Stock
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Purity:98.36%
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Product Introduction

Bioactivity
Description
Fantofarone (SR 33557) is a highly potent antagonist of Calcium Channel.
In vitro
Calcium channel blockers VIZ and Fantofarone (SR) exhibit modest antimalarial effects compared to chloroquine (CQ), with slightly greater efficacy against CQ-resistant parasites. Notably, Fantofarone is approximately 10 times more effective than verapamil. Isobologram analysis indicates these blockers enhance CQ sensitivity in CQ-resistant P. falciparum, with verapamil being 2 to 3 times more effective than Fantofarone in reducing CQ resistance at comparable subinhibitory concentrations.
In vivo
Administration of isosorbide dinitrate (0.3 mg/kg, i.v.) or Fantofarone (50 mg/kg, i.v.) results in a decrease in both the frequency and severity of vasospasm, with Fantofarone showing the greatest efficacy in mitigating vasospasm across both distal and proximal regions. In contrast, verapamil (0.2 mg/kg, i.v.) exhibits markedly less effectiveness. While isosorbide dinitrate effectively suppresses distal arterial intraluminal volume (AIV) reduction, it does not significantly impact the decrease in proximal diameter. Conversely, Fantofarone stands out for its substantial reduction of AIV across the experiment, whereas verapamil fails to significantly affect AIV.
Animal Research
Male White rabbits are used in this study (3.0-3.2 kg). All surgical procedures are performed under anaesthesia with a mixture of ketamine and xylazine. At the end of the experiments, the animals are sacrificed by a pentobarbital overdose. The proximal femoral arteries are exposed, and the isolated arterial segments are desiccated by air infusion delivered at a rate of 80 mL/min for 8 min. After desiccation is completed, the ligatures are released and flow is restored. At the day of surgery, a 2% cholesterol/6% peanut oil diet is started for 2 weeks. Before angioplasty, the animals are randomized in 4 groups of 10 animals:1. Placebo, 1 mL/kg of NaCl 0.9%, 2. Isosorbide dinitrate, 0.3 mg/kg, 3. Verapamil, 0.2 mg/kg, 4. Fantofarone, 50 mg/kg. The doses of isosorbide dinitrate, verapamil, and fantofarone are defined in a pilot experiment as the highest doses which did not show any hypotensive effect per se and are chosen very carefully according to their activity measured in other pharmacological models.
AliasSR 33557
Chemical Properties
Molecular Weight550.71
FormulaC31H38N2O5S
Cas No.114432-13-2
SmilesCOc1ccc(CCN(C)CCCOc2ccc(cc2)S(=O)(=O)c2c(cn3ccccc23)C(C)C)cc1OC
Relative Density.1.16g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 150 mg/mL (272.38 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8158 mL9.0792 mL18.1584 mL90.7919 mL
5 mM0.3632 mL1.8158 mL3.6317 mL18.1584 mL
10 mM0.1816 mL0.9079 mL1.8158 mL9.0792 mL
20 mM0.0908 mL0.4540 mL0.9079 mL4.5396 mL
50 mM0.0363 mL0.1816 mL0.3632 mL1.8158 mL
100 mM0.0182 mL0.0908 mL0.1816 mL0.9079 mL

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