Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Galanthamine hydrobromide

Galanthamine hydrobromide
Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.
Catalog No. T0086Cas No. 1953-04-4
Select Batch
Purity:100%
Contact us for more batch information

Resource Download

Galanthamine hydrobromide

Catalog No. T0086Alias Galanthamine HBr, Galantamine hydrobromideCas No. 1953-04-4

Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
50 mg$29In Stock
100 mg$37In Stock
500 mg$125In Stock
1 g$183In Stock
1 mL x 10 mM (in DMSO)$34In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "Galanthamine hydrobromide"

Product Introduction

Bioactivity
Description
Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.
Targets&IC50
AChE:410 nM
In vitro
Galanthamine has been demonstrated to have an IC50 of 14 nM and 15 nM on AChE in post-mortem human brain frontal cortex and the hippocampus region. Red-cell cholinesterase activity in blood samples from the neurosurgery patients is 10 times more strongly inhibited by Galanthamine in brain tissue samples. [1] Galanthamine (1 μM) activates single channels with conductance's of 18 and 30 pS in outside-out patches excised from dexamethasone mouse fibroblasts (M10 cells). [2] Galanthamine acts as noncompetitive nicotinic receptor agonists' on clonal rat pheochromocytoma (PC12) cells. Galanthamine (50 μM) activates single-channel currents in outside-out patches excised from clonal PC12 cells. [3]
In vivo
Galantamine significantly increases the number of living pyramidal neurons after ischemia-reperfusion injury. Galantamine significantly reduces TUNEL, active caspase-3, and SOD-2 immunoreactivity. The nicotinic antagonist mecamylamine blockes the protective effects of galantamine. The neuroprotective effects of galantamine are preserved even when first administered at 3 hours postischemia. [4]
AliasGalanthamine HBr, Galantamine hydrobromide
Chemical Properties
Molecular Weight368.27
FormulaC17H21NO3·HBr
Cas No.1953-04-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/mL (162.92 mM), Heating is recommended.
H2O: 7.4 mg/mL (20 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.7154 mL13.5770 mL27.1540 mL135.7700 mL
5 mM0.5431 mL2.7154 mL5.4308 mL27.1540 mL
10 mM0.2715 mL1.3577 mL2.7154 mL13.5770 mL
20 mM0.1358 mL0.6788 mL1.3577 mL6.7885 mL
DMSO
1mg5mg10mg50mg
50 mM0.0543 mL0.2715 mL0.5431 mL2.7154 mL
100 mM0.0272 mL0.1358 mL0.2715 mL1.3577 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy Galanthamine hydrobromide | purchase Galanthamine hydrobromide | Galanthamine hydrobromide cost | order Galanthamine hydrobromide | Galanthamine hydrobromide chemical structure | Galanthamine hydrobromide in vivo | Galanthamine hydrobromide in vitro | Galanthamine hydrobromide formula | Galanthamine hydrobromide molecular weight