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Galanthamine hydrobromide

Catalog No. T0086Cas No. 1953-04-4
Alias Galanthamine HBr, Galantamine hydrobromide

Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.

Galanthamine hydrobromide

Galanthamine hydrobromide

Purity: 100%
Catalog No. T0086Alias Galanthamine HBr, Galantamine hydrobromideCas No. 1953-04-4
Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.
Pack SizePriceAvailabilityQuantity
25 mg$36In Stock
50 mg$52In Stock
100 mg$62In Stock
500 mg$208In Stock
1 mL x 10 mM (in DMSO)$57In Stock
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Product Introduction

Bioactivity
Description
Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.
Targets&IC50
AChE:410 nM
In vitro
Galanthamine has been demonstrated to have an IC50 of 14 nM and 15 nM on AChE in post-mortem human brain frontal cortex and the hippocampus region. Red-cell cholinesterase activity in blood samples from the neurosurgery patients is 10 times more strongly inhibited by Galanthamine in brain tissue samples. [1] Galanthamine (1 μM) activates single channels with conductance's of 18 and 30 pS in outside-out patches excised from dexamethasone mouse fibroblasts (M10 cells). [2] Galanthamine acts as noncompetitive nicotinic receptor agonists' on clonal rat pheochromocytoma (PC12) cells. Galanthamine (50 μM) activates single-channel currents in outside-out patches excised from clonal PC12 cells. [3]
In vivo
Galantamine significantly increases the number of living pyramidal neurons after ischemia-reperfusion injury. Galantamine significantly reduces TUNEL, active caspase-3, and SOD-2 immunoreactivity. The nicotinic antagonist mecamylamine blockes the protective effects of galantamine. The neuroprotective effects of galantamine are preserved even when first administered at 3 hours postischemia. [4]
AliasGalanthamine HBr, Galantamine hydrobromide
Chemical Properties
Molecular Weight368.27
FormulaC17H21NO3·HBr
Cas No.1953-04-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/mL (162.92 mM), Heating is recommended.
H2O: 7.4 mg/mL (20 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.7154 mL13.5770 mL27.1540 mL135.7700 mL
5 mM0.5431 mL2.7154 mL5.4308 mL27.1540 mL
10 mM0.2715 mL1.3577 mL2.7154 mL13.5770 mL
20 mM0.1358 mL0.6788 mL1.3577 mL6.7885 mL
DMSO
1mg5mg10mg50mg
50 mM0.0543 mL0.2715 mL0.5431 mL2.7154 mL
100 mM0.0272 mL0.1358 mL0.2715 mL1.3577 mL

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