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LY310762

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Purity:98%

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COA HNMR

LY310762

Catalog No. T2688Cas No. 192927-92-7

LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.

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Pack Size	Price	Availability
5 mg	$45	In Stock
10 mg	$72	In Stock
25 mg	$147	In Stock
100 mg	$382	In Stock
200 mg	$579	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock

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Product Introduction

Bioactivity

Description	LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.
In vitro	Following treatment with LY310762, the levels of 5-HT in animals treated with fluoxetine increased from 312±43% to a peak of 683%. In the control group, the 5-HT levels remained constant at 250%. Compared to animals that received a control vehicle injection, systemic administration of 10 mg/kg i.p. LY310762 significantly enhanced the response of 5-HT to 20 mg/kg i.p. fluoxetine. When administered alone, LY310762 notably raised the baseline levels of 5-HT above the vehicle control, achieving a maximum value of 258% compared to the pre-injection control group.
In vivo	LY310762 enhances potassium-induced [3H] 5-HT efflux from guinea pig cortical slices, with an EC50 of 30 nM. The maximal enhancement of potassium-induced [3H]5-HT efflux by LY310762 is approximately 40%. LY310762 exhibits a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor.
Alias	LY310762 HCl

Chemical Properties

Molecular Weight	430.94
Formula	C24H27FN2O2·HCl
Cas No.	192927-92-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 43.1 mg/mL (100 mM)

H2O: 4.3 mg/mL (10 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.3205 mL	11.6025 mL	23.2051 mL	116.0254 mL
5 mM	0.4641 mL	2.3205 mL	4.6410 mL	23.2051 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2321 mL	1.1603 mL	2.3205 mL	11.6025 mL
20 mM	0.1160 mL	0.5801 mL	1.1603 mL	5.8013 mL
50 mM	0.0464 mL	0.2321 mL	0.4641 mL	2.3205 mL
100 mM	0.0232 mL	0.1160 mL	0.2321 mL	1.1603 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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