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palovarotene
🥰Excellent
Catalog No. T4538Cas No. 410528-02-8
Alias Ro 3300074, R 667
Palovarotene (Ro 3300074) is an agonist of nuclear retinoic acid receptor γ (RAR-γ).
palovarotene
🥰Excellent
Purity: 98.05%
Catalog No. T4538Alias Ro 3300074, R 667Cas No. 410528-02-8
Palovarotene (Ro 3300074) is an agonist of nuclear retinoic acid receptor γ (RAR-γ).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $33 | In Stock | |
| 5 mg | $68 | In Stock | |
| 10 mg | $113 | In Stock | |
| 25 mg | $263 | In Stock | |
| 50 mg | $419 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $109 | In Stock |
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Purity:98.05%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Palovarotene (Ro 3300074) is an agonist of nuclear retinoic acid receptor γ (RAR-γ). |
| In vivo | Palovarotene effectively hinders post-traumatic chondrogenesis, osteogenesis, and significantly reduces trauma-induced ectopic bone formation. Through oral administration (1 mg/kg/day for 14 days, starting from either the first or fifth day post-operation), this compound markedly decreases subcutaneous and intramuscular heterotopic ossification (HO) in mice, achieving a reduction of 50 to 60% in HO, irrespective of treatment initiation timing or infection presence. In a specific study, Acvr1cR206H/+ mice were divided into two groups: one treated with Palovarotene and the other with a vehicle control for 14 days beginning on the injury's first day. Comparative analysis using micro-CT and 3D imaging on the 14th day revealed that while significant HO tissue masses developed in the vehicle-treated group, Palovarotene-treated mice showed over an 80% reduction in HO formation, based on bone volume/total volume metrics. |
| Alias | Ro 3300074, R 667 |
| Molecular Weight | 414.54 |
| Formula | C27H30N2O2 |
| Cas No. | 410528-02-8 |
| Smiles | CC1(C)CCC(C)(C)c2cc(\C=C\c3ccc(cc3)C(O)=O)c(Cn3cccn3)cc12 |
| Relative Density. | 1.11 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 5.5 mg/mL (13.27 mM)  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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