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pCPA methyl ester hydrochloride

Catalog No. T41143   CAS 14173-40-1
Synonyms: 4-Chloro-DL-phenylalanine methyl ester hydrochloride

pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) is an inhibitor of tryptophan hydroxylase inhibitor and 5-HT synthesis. pCPA methyl ester hydrochloride is permeable across the blood-brain barrier and reduces 5-HT central availability.

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pCPA methyl ester hydrochloride Chemical Structure
pCPA methyl ester hydrochloride, CAS 14173-40-1
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Purity: 99.08%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) is an inhibitor of tryptophan hydroxylase inhibitor and 5-HT synthesis. pCPA methyl ester hydrochloride is permeable across the blood-brain barrier and reduces 5-HT central availability.
In vivo In C57BL/6 elite male mice, 5-HT levels decreased by 85% and 55% in the hippocampus of mice treated with oral or i.p. PCPA methyl ester hydrochloride(250, 500 mg/kg), respectively, whereas in the prefrontal cortex, 5-HT levels decreased by 65% and 50%[4].
Synonyms 4-Chloro-DL-phenylalanine methyl ester hydrochloride
Molecular Weight 250.12
Formula C10H13Cl2NO2
CAS No. 14173-40-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 45 mg/mL (179.91 mM), ultrasonic and warming and heat to 60°C

DMSO: 245 mg/mL (979.53 mM), sonification is recommended.

TargetMolReferences and Literature

1. Fabio Bellia, et al. Transient serotonin depletion at adolescence, but not at early infancy, reduced subsequent anxiety-like behavior and alcohol intake in female mice. Psychopharmacology (Berl). 2021 Jan;238(1):215-225. 2. Wallace et al (2014) Vort. restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats. Int.J.Neuropsychopharmacol. 17 1695 PMID: 24852131 3. Dool-Ri Oh, et al. Sedative and hypnotic effects of Vaccinium bracteatum Thunb. through the regulation of serotonegic and GABA A-ergic systems: Involvement of 5-HT 1A receptor agonistic activity. Biomed Pharmacother. 2019 Jan;109:2218-2227. 4. ocío B Foltran, et al. Neurochemical, Behavioral, and Neurogenic Validation of a Hyposerotonergic Animal Model by Voluntary Oral Consumption of para-Chlorophenylalanine. ACS Chem Neurosci. 2020 Mar 18;11(6):952-959. 5. Pinto Brod et al (2016) Involvement of monoaminergic system in the antidepressant-like effect of (octylseleno)-xylofuranoside in the mouse tail suspension test. Prog.Neuropsychopharmacol.Biol.Psychiatry. 65 201 PMID: 26596986

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Inhibitor Library Bioactive Compound Library Neuronal Signaling Compound Library Metabolism Compound Library Neurotransmitter Receptor Compound Library Anti-Cancer Compound Library

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Keywords

pCPA methyl ester hydrochloride 14173-40-1 GPCR/G Protein Metabolism Neuroscience 5-HT Receptor Hydroxylase 5-HT Inhibitor PCPA methyl ester insomnia pCPA methyl ester Hydrochloride reversible 5-hydroxytryptamine Receptor BBB Serotonin Receptor 4-Chloro-DL-phenylalanine methyl ester hydrochloride inhibit Tryptophan Hydroxylase inhibitor

 

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