Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

PD-168077 maleate

🥰Excellent
Catalog No. T5047Cas No. 630117-19-0

PD-168077 maleate is a selective agonist of the dopamine D4 receptor (Ki: 9 nM).

PD-168077 maleate

PD-168077 maleate

🥰Excellent
Purity: 98.82%
Catalog No. T5047Cas No. 630117-19-0
PD-168077 maleate is a selective agonist of the dopamine D4 receptor (Ki: 9 nM).
Pack SizePriceAvailabilityQuantity
2 mg$30In Stock
5 mg$48In Stock
10 mg$73In Stock
25 mg$153In Stock
50 mg$257In Stock
100 mg$383In Stock
200 mg$545In Stock
1 mL x 10 mM (in DMSO)$53In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "PD-168077 maleate"

Select Batch
Purity:98.82%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
PD-168077 maleate is a selective agonist of the dopamine D4 receptor (Ki: 9 nM).
Targets&IC50
D4:9 nM(Ki)
In vivo
PD-168077, a selective D4 dopamine receptor agonist, injected into the paraventricular nucleus of the hypothalamus on penile erection was studied in male rats.?PD-168077 (1-200 ng) induced penile erection in a dose-dependent manner.?The minimal effective dose was 50 ng, while the maximal response was found with 200 ng of the compound, which increased penile erection episodes from 0.3+/-0.03 to 1.7+/-0.21.?The proerectile effect of PD-168077 was reduced almost completely by L-745,870 (3-(4-[chlorophenyl]piperazin-1-yl)-methyl-1H-pyrrolo[2,3-B]pyridine trihydrochloride), a selective D4 dopamine receptor antagonist, (1 microg) given into the paraventricular nucleus before the D4 dopamine agonist, and by other nonselective dopamine receptor antagonists, such as haloperidol (1 microg) and clozapine (1 microg), which block all dopamine receptor subtypes.?The pro-erectile effect of PD-168077 was also reduced by the NO synthase inhibitor NG-nitro-L-arginine methylester (25 microg), but not by the oxytocin receptor antagonist d(CH2)5Tyr(Me)2-Orn8-vasotocin (1 microg), when given into the paraventricular nucleus.?In spite of its inability to prevent the pro-erectile effect of PD-168077 when given in the paraventricular nucleus, d(CH2)5Tyr(Me)2-Orn8-vasotocin (1 microg) reduced almost completely PD-168077-induced penile erection when given into the lateral ventricles[1].
Chemical Properties
Molecular Weight450.49
FormulaC24H26N4O5
Cas No.630117-19-0
SmilesOC(=O)\C=C/C(O)=O.Cc1cccc(c1)C(=O)NCN1CCN(CC1)c1ccccc1C#N
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 150 mg/mL (332.97 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2198 mL11.0990 mL22.1981 mL110.9903 mL
5 mM0.4440 mL2.2198 mL4.4396 mL22.1981 mL
10 mM0.2220 mL1.1099 mL2.2198 mL11.0990 mL
20 mM0.1110 mL0.5550 mL1.1099 mL5.5495 mL
50 mM0.0444 mL0.2220 mL0.4440 mL2.2198 mL
100 mM0.0222 mL0.1110 mL0.2220 mL1.1099 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy PD-168077 maleate | purchase PD-168077 maleate | PD-168077 maleate cost | order PD-168077 maleate | PD-168077 maleate chemical structure | PD-168077 maleate in vivo | PD-168077 maleate formula | PD-168077 maleate molecular weight