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Pipecuronium bromide

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Catalog No. T12481Cas No. 52212-02-9
Alias RGH-1106

Pipecuronium bromide (RGH-1106) is a selective and potent nAChR antagonist that also acts as a non-depolarising steroidal neuromuscular blocker, causing muscle relaxation, often in conjunction with antibiotics.

Pipecuronium bromide

Pipecuronium bromide

🥰Excellent
Purity: 100%
Catalog No. T12481Alias RGH-1106Cas No. 52212-02-9
Pipecuronium bromide (RGH-1106) is a selective and potent nAChR antagonist that also acts as a non-depolarising steroidal neuromuscular blocker, causing muscle relaxation, often in conjunction with antibiotics.
Pack SizePriceAvailabilityQuantity
1 mg28 €In Stock
5 mg64 €In Stock
10 mg100 €In Stock
25 mg202 €In Stock
50 mg329 €In Stock
100 mg525 €In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Pipecuronium bromide (RGH-1106) is a selective and potent nAChR antagonist that also acts as a non-depolarising steroidal neuromuscular blocker, causing muscle relaxation, often in conjunction with antibiotics.
In vitro
Sugammadex exhibits a high affinity for Pipecuronium bromide, which is 6 to 7 times more potent than Rocuronium, thereby enabling a more effective molecular blockade compared to Rocuronium [3].
In vivo
Sugammadex adequately and rapidly reverses pipecuronium bromide induced moderate NMB during sevoflurane anesthesia. Once the train-of-four count has spontaneously returned to 2 responses following pipecuronium bromide administration, a dose of 2.0 mg/kg of sugammadex is sufficient to reverse the NMB[2].Carboxymethylated γ-cyclodextrin demonstrates efficient and complete reversal of the Pipecuronium bromide-induced neuromuscular block in an ex vivo rat diaphragm experiment [1].
AliasRGH-1106
Chemical Properties
Molecular Weight762.7
FormulaC35H62Br2N4O4
Cas No.52212-02-9
SmilesC[C@@]12[C@](C[C@H](N3CC[N+](C)(CC3)C)[C@@H]2OC(C)=O)([H])[C@@]4([H])[C@@](CC1)([H])[C@@]5([C@@](C[C@@H]([C@@H](N6CC[N+](C)(CC6)C)C5)OC(C)=O)([H])CC4)C.[Br-].[Br-]
Relative Density.1.329
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 80 mg/mL (104.89 mM), Sonication is recommended.
DMSO: 120 mg/mL (157.34 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.3111 mL6.5557 mL13.1113 mL65.5566 mL
5 mM0.2622 mL1.3111 mL2.6223 mL13.1113 mL
10 mM0.1311 mL0.6556 mL1.3111 mL6.5557 mL
20 mM0.0656 mL0.3278 mL0.6556 mL3.2778 mL
50 mM0.0262 mL0.1311 mL0.2622 mL1.3111 mL
100 mM0.0131 mL0.0656 mL0.1311 mL0.6556 mL

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