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Pipecuronium bromide
Catalog No. T12481Cas No. 52212-02-9
Alias RGH-1106
Pipecuronium bromide (RGH-1106) is a selective and potent nAChR antagonist that also acts as a non-depolarising steroidal neuromuscular blocker, causing muscle relaxation, often in conjunction with antibiotics.
Pipecuronium bromide
Catalog No. T12481Alias RGH-1106Cas No. 52212-02-9
Pipecuronium bromide (RGH-1106) is a selective and potent nAChR antagonist that also acts as a non-depolarising steroidal neuromuscular blocker, causing muscle relaxation, often in conjunction with antibiotics.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 5 mg | $68 | In Stock | |
| 10 mg | $106 | In Stock | |
| 25 mg | $213 | In Stock | |
| 50 mg | $347 | In Stock | |
| 100 mg | $553 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Pipecuronium bromide (RGH-1106) is a selective and potent nAChR antagonist that also acts as a non-depolarising steroidal neuromuscular blocker, causing muscle relaxation, often in conjunction with antibiotics. |
| In vitro | Sugammadex exhibits a high affinity for Pipecuronium bromide, which is 6 to 7 times more potent than Rocuronium, thereby enabling a more effective molecular blockade compared to Rocuronium [3]. |
| In vivo | Sugammadex adequately and rapidly reverses pipecuronium bromide induced moderate NMB during sevoflurane anesthesia. Once the train-of-four count has spontaneously returned to 2 responses following pipecuronium bromide administration, a dose of 2.0 mg/kg of sugammadex is sufficient to reverse the NMB[2].Carboxymethylated γ-cyclodextrin demonstrates efficient and complete reversal of the Pipecuronium bromide-induced neuromuscular block in an ex vivo rat diaphragm experiment [1]. |
| Alias | RGH-1106 |
| Molecular Weight | 762.7 |
| Formula | C35H62Br2N4O4 |
| Cas No. | 52212-02-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 80 mg/mL (104.89 mM), Sonication is recommended. DMSO: 120 mg/mL (157.34 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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