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Pivagabine

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COA HNMR

Pivagabine

Catalog No. T12492Cas No. 69542-93-4

Pivagabine (CXB-722), a hydrophobic 4-aminobutyric acid derivative, exhibits neuromodulatory activity and successfully penetrates the blood-brain barrier in rats. It counteracts the impact of foot shock on GABAA receptor function and corticotropin-releasing factor (CRF) levels in the rat brain.

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Pack Size	Price	Availability
1 mg	$30	In Stock
2 mg	$40	In Stock
5 mg	$64	In Stock
10 mg	$106	In Stock
25 mg	$176	In Stock
50 mg	$262	In Stock
100 mg	$389	In Stock
500 mg	$882	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock

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Product Introduction

Bioactivity

Description	Pivagabine (CXB-722), a hydrophobic 4-aminobutyric acid derivative, exhibits neuromodulatory activity and successfully penetrates the blood-brain barrier in rats. It counteracts the impact of foot shock on GABAA receptor function and corticotropin-releasing factor (CRF) levels in the rat brain.
In vivo	Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions[2].
Animal Research	Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions, reduced by 52% the CRF concentration in the hypothalamus but had no effect on that in the cerebral cortex[2].
Alias	CXB-722

Chemical Properties

Molecular Weight	187.24
Formula	C9H17NO3
Cas No.	69542-93-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (240.33 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.3407 mL	26.7037 mL	53.4074 mL	267.0370 mL
5 mM	1.0681 mL	5.3407 mL	10.6815 mL	53.4074 mL
10 mM	0.5341 mL	2.6704 mL	5.3407 mL	26.7037 mL
20 mM	0.2670 mL	1.3352 mL	2.6704 mL	13.3518 mL
50 mM	0.1068 mL	0.5341 mL	1.0681 mL	5.3407 mL
100 mM	0.0534 mL	0.2670 mL	0.5341 mL	2.6704 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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