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Rosiglitazone hydrochloride
🥰Excellent
Catalog No. T6646Cas No. 302543-62-0
Alias Rosiglitazone HCl, BRL-49653 HCl
Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
Rosiglitazone hydrochloride
🥰Excellent
Purity: 99.79%
Catalog No. T6646Alias Rosiglitazone HCl, BRL-49653 HClCas No. 302543-62-0
Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $33 | In Stock | |
| 50 mg | $45 | In Stock | |
| 100 mg | $62 | In Stock | |
| 200 mg | $88 | In Stock | |
| 500 mg | $143 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock |
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Purity:99.79%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells. |
| Targets&IC50 | PPARγ2:100 nM (EC50), PPARγ1:30 nM (EC50) |
| In vitro | Bafetinib blocks WT Bcr-Abl autophosphorylation and its downstream kinase activity with IC50 of 11 nM and 22 nM in K562 and 293T cells, respectively. Bafetinib suppresses the growth of the Bcr-Abl-positive cell lines including K562, KU812, and BaF3/wt cells potently without effects on the proliferation of the Bcr-Abl-negative U937 cell line. Moreover, Bafetinib exhibits a dose-dependent antiproliferative effect against Bcr-Abl point mutant cell lines, such as BaF3/E255K cells. [1] In Bcr-Abl+ leukemia cell lines, Bafetinib induces both caspase-mediated and caspase-independent cell death by blocking the phosphorylation of Bcr-Abl. [2] |
| Alias | Rosiglitazone HCl, BRL-49653 HCl |
| Molecular Weight | 393.89 |
| Formula | C18H19N3O3S·HCl |
| Cas No. | 302543-62-0 |
| Smiles | Cl.CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 73 mg/mL (185.3 mM) DMSO: 73 mg/mL (185.3 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
TRPVChannelTRPV ChannelTRPChannelTRP ChannelTransient receptor potential channelssmokesenescenceRosiglitazone HydrochlorideRosiglitazone hydrochlorideRosiglitazonePPARγPPARPeroxisome proliferator-activated receptorsovarian cancerneuroprotectionmellitusInhibitorinhibithepatocellularHCCFerroptosisdiabeticdiabetescarcinomacancerBRL-49653BRL49653BRL 49653bladderAutophagyApoptosisantihyperglycemic
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