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RS102895 hydrochloride

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Purity:99.7%

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COA HNMR HPLC

RS102895 hydrochloride

Catalog No. T12773Cas No. 1173022-16-6

RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).

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Pack Size	Price	Availability
2 mg	$40	In Stock
5 mg	$60	In Stock
10 mg	$90	In Stock
25 mg	$189	In Stock
50 mg	$337	In Stock
100 mg	$506	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock

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Product Introduction

Bioactivity

Description	RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).
In vitro	RS102895 hydrochloride is a potent antagonist of CCR2(IC50 : 360 nM). RS102895 inhibits human α1a and α1d receptors, rat brain cortex 5HT1a receptor in cells with IC50s of 130, 320, 470 nM, respectively. RS102895 suppresses wild type and D284N mutant MCP-1 receptor with IC50 of 550 nM and 568 nM, respectively. RS102895 less potently inhibits D284A MCP-1 receptor with IC50 of 1892 nM. RS102895 ameliorates the increased extracellular matrix (ECM) protein expression by inhibition of CCR2 at 10 μM, and obviously blocks fibronectin and type IV collagen protein expression in high glucose (HG)-stimulated mesangial cells (MCs) at 1 or 10 μM. RS102895 (10 μM) also abrogates the increased TGF-1 levels in MCs treated with MCP-1[2].
In vivo	Progressive decrease in pain threshold in rats with bone cancer pain (BCP) at day 3-9 after surgery via intrathecal injection caused by RS102895 (3 g/L), but the pain threshold increases after 12 days. RS102895 also potently reverses the pattern of NR2B, nNOS, and SIGIRR expression in spinal cord[3].

Chemical Properties

Molecular Weight	426.86
Formula	C21H22ClF3N2O2
Cas No.	1173022-16-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 28 mg/mL (65.60 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3427 mL	11.7134 mL	23.4269 mL	117.1344 mL
5 mM	0.4685 mL	2.3427 mL	4.6854 mL	23.4269 mL
10 mM	0.2343 mL	1.1713 mL	2.3427 mL	11.7134 mL
20 mM	0.1171 mL	0.5857 mL	1.1713 mL	5.8567 mL
50 mM	0.0469 mL	0.2343 mL	0.4685 mL	2.3427 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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