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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $38 | In Stock | |
2 mg | $54 | In Stock | |
5 mg | $89 | In Stock | |
10 mg | $133 | In Stock | |
25 mg | $239 | In Stock | |
50 mg | $378 | In Stock | |
100 mg | $558 | In Stock | |
500 mg | $1,190 | In Stock | |
1 mL x 10 mM (in DMSO) | $87 | In Stock |
Description | TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders. |
In vitro | TMPH (100 nM) inhibits nAChR with an inhibition rate of 90% in Xenopus oocytes and suppresses AChR subtypes with IC50s of 1.0-390 nM[1]. |
In vivo | In the nicotine-induced mice model, nAChR-IN-1 (20 mg/kg; s.c.) increases locomotor activity without effects on body temperature. In the tail-flick and hot-plate mice model, nAChR-IN-1(0, 0.1, 1, 5 mg/kg; s.c.) blocks the antinociceptive effect of nicotine in the hot-plate and blocks antinociception in a time-dependent manner[1]. |
Alias | 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate |
Molecular Weight | 269.42 |
Formula | C16H31NO2 |
Cas No. | 849461-90-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (185.58 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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