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VU0467154

VU0467154
VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (M4 mAChR).
Catalog No. T17244Cas No. 1451993-15-9
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Purity:98.28%
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VU0467154

Catalog No. T17244Cas No. 1451993-15-9

VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (M4 mAChR).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$41In Stock
2 mg$59In Stock
5 mg$97In Stock
10 mg$133In Stock
25 mg$263In Stock
50 mg$446In Stock
100 mg$657In Stock
1 mL x 10 mM (in DMSO)$107In Stock
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Product Introduction

Bioactivity
Description
VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (M4 mAChR).
Targets&IC50
M4 mAChR:6(pEC50,Cynomolgus monkey), M4 mAChR:6.2(pEC50,human), M4 mAChR:7.75(pEC50, rat)
In vitro
VU0467154 potentiates the response to ACh with pEC50s of 7.75(rat), 6.2(human) and 6(cynomolgus monkey) for M4 receptor, respectively. VU0467154 does not potentiate the ACh response at rat and human M1, M2, M3, or M5[1].
In vivo
VU0467154 produced a robust dose-dependent reversal of MK-801-induced hyperlocomotion and deficits in preclinical models of associative learning and memory functions, including the touchscreen pairwise visual discrimination task in wild-type mice, but failed to reverse these stimulant-induced deficits in M4 KO mice[1]. VU0467154 also enhanced the acquisition of both contextual and cue-mediated fear conditioning when administered alone in wild-type mice[1].
Chemical Properties
Molecular Weight444.45
FormulaC17H15F3N4O3S2
Cas No.1451993-15-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (123.75 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2500 mL11.2499 mL22.4997 mL112.4986 mL
5 mM0.4500 mL2.2500 mL4.4999 mL22.4997 mL
10 mM0.2250 mL1.1250 mL2.2500 mL11.2499 mL
20 mM0.1125 mL0.5625 mL1.1250 mL5.6249 mL
50 mM0.0450 mL0.2250 mL0.4500 mL2.2500 mL
100 mM0.0225 mL0.1125 mL0.2250 mL1.1250 mL

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