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ZM 336372

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Purity:97.24%

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COA HPLC HNMR

ZM 336372

Catalog No. T1851Cas No. 208260-29-1

ZM 336372 is a potent and selective c-Raf inhibitor.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
2 mg	$34	In Stock
5 mg	$53	In Stock
10 mg	$88	In Stock
25 mg	$166	In Stock
50 mg	$302	In Stock
100 mg	$529	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock

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Questions

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Product Introduction

Bioactivity

Description	ZM 336372 is a potent and selective c-Raf inhibitor.
Kinase Assay	In vitro kinase assay: c-Raf kinase activity is assayed directly in Sl9 cell lysates. Human c-Raf is activated in Sf9 cells by cotransfection from baculovirus vectors containing DNA encoding v-Ras and Lck in the absence of ZM 336372. The cell lysates are then assayed for c-Raf activity in the presence of increasing concentrations of ZM 336372.
Cell Research	Cells are exposed to various concentrations of ZM 336372 for 48 and 72 hours. After incubation, the medium is removed and cells are trypsinized. Cells are incubated on ice, and 2.5 μg/mL propidium iodide is added 5 minutes before flow cytometry. Data is acquired using a FACSCalibur benchtop flow cytometer using CellQuest acquisition and analysis software. Cytotoxicity is done using Cell Titer Glo Assay. Cell proliferation is measured using MTT assay.(Only for Reference)
Alias	Zinc00581684

Chemical Properties

Molecular Weight	389.45
Formula	C23H23N3O3
Cas No.	208260-29-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 2 mg/mL (5.13 mM)

DMSO: 72 mg/mL (184.9 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.5677 mL	12.8386 mL	25.6772 mL	128.3862 mL
5 mM	0.5135 mL	2.5677 mL	5.1354 mL	25.6772 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2568 mL	1.2839 mL	2.5677 mL	12.8386 mL
20 mM	0.1284 mL	0.6419 mL	1.2839 mL	6.4193 mL
50 mM	0.0514 mL	0.2568 mL	0.5135 mL	2.5677 mL
100 mM	0.0257 mL	0.1284 mL	0.2568 mL	1.2839 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc