Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 77.00 | |
10 mg | In stock | $ 126.00 | |
25 mg | In stock | $ 230.00 | |
50 mg | In stock | $ 369.00 | |
100 mg | In stock | $ 549.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 84.00 |
Description | Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity. |
In vitro | CC-122 is a novel agent for DLBCL with antitumor and immunomodulatory activity. In DLBCL cell lines, It binds CRBN and induces degradation or short hairpin RNA-mediated knockdown of Aiolos and Ikaros which correlates with increased transcription of interferon (IFN)-stimulated genes independent of IFN-α, -β, and -γ production and/or secretion and results in apoptosis in both activated B-cell (ABC) and germinal center B-cell DLBCL cell lines. CRBN is the molecular target of CC-122, CC-122 binding to CRBN recruits Aiolos/Ikaros to CRL4CRBN, and E3 ligase enzymatic activity is necessary for ubiquitination of Aiolos and Ikaros and thus their proteasomal degradation induced by CC-122. CC-122 induces IFN-regulated proteins and its mediated effects on the IFN pathway is independent of autocrine type I and II IFN secretion and signaling[1]. |
In vivo | CC-122 reduces tumor growth in xenograft models established from ABC- and GCB-DLBCL cell lines, and stimulates IL-2 production in primary T cells. Also, in a single-arm CC-122 Clinicalal trial, exposure to CC-122 reduced expression levels of Aiolos and Ikaros in each patient by 25% to 50% demonstrating the utility of these 2 proteins as pharmacodynamic markers of CC-122[1]. |
Cell Research | Diffuse Large B-Cell Lymphoma are cultured in RPMI-1640 containing 10-20% fetal bovine serum, 1% Penicillin/Streptomycin and 1 mM sodium pyruvate. 2×104 cells are plated per well in media containing either DMSO or various concentrations of CC-122. Cells are cultured for 5 days at 37 degrees Celsius after which tritiated thymidine is added to the cell culture for the final 6 hours. Cells are subsequently harvested onto filter plates. After the plates have dried, scintillation fluid is added to the plates and read on a Top-count reader(Only for Reference) |
Synonyms | CC 122 |
Molecular Weight | 286.29 |
Formula | C14H14N4O3 |
CAS No. | 1015474-32-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 1 mg/mL (3.49 mM)
DMSO: 52 mg/mL(181.7 mM)
You can also refer to dose conversion for different animals. More
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Avadomide 1015474-32-4 Apoptosis PROTAC Ubiquitination E1/E2/E3 Enzyme Ligand for E3 Ligase orally diffuse CC122 CC-122 B-cell Inhibitor DLBCL Ubiquitin ligase E3 ligating enzyme immunomodulatory cereblon E1 activating enzyme ligase E2 conjugating enzyme large CC 122 Ubiquitin conjugating enzyme Ubiquitin activating enzyme antitumor inhibit lymphoma inhibitor