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Avadomide

Catalog No. T3549   CAS 1015474-32-4
Synonyms: CC 122

Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity.

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Avadomide Chemical Structure
Avadomide, CAS 1015474-32-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
2 mg In stock $ 48.00
5 mg In stock $ 77.00
10 mg In stock $ 126.00
25 mg In stock $ 230.00
50 mg In stock $ 369.00
100 mg In stock $ 549.00
1 mL * 10 mM (in DMSO) In stock $ 84.00
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Purity: 99.07%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity.
In vitro CC-122 is a novel agent for DLBCL with antitumor and immunomodulatory activity. In DLBCL cell lines, It binds CRBN and induces degradation or short hairpin RNA-mediated knockdown of Aiolos and Ikaros which correlates with increased transcription of interferon (IFN)-stimulated genes independent of IFN-α, -β, and -γ production and/or secretion and results in apoptosis in both activated B-cell (ABC) and germinal center B-cell DLBCL cell lines. CRBN is the molecular target of CC-122, CC-122 binding to CRBN recruits Aiolos/Ikaros to CRL4CRBN, and E3 ligase enzymatic activity is necessary for ubiquitination of Aiolos and Ikaros and thus their proteasomal degradation induced by CC-122. CC-122 induces IFN-regulated proteins and its mediated effects on the IFN pathway is independent of autocrine type I and II IFN secretion and signaling[1].
In vivo CC-122 reduces tumor growth in xenograft models established from ABC- and GCB-DLBCL cell lines, and stimulates IL-2 production in primary T cells. Also, in a single-arm CC-122 Clinicalal trial, exposure to CC-122 reduced expression levels of Aiolos and Ikaros in each patient by 25% to 50% demonstrating the utility of these 2 proteins as pharmacodynamic markers of CC-122[1].
Cell Research Diffuse Large B-Cell Lymphoma are cultured in RPMI-1640 containing 10-20% fetal bovine serum, 1% Penicillin/Streptomycin and 1 mM sodium pyruvate. 2×104 cells are plated per well in media containing either DMSO or various concentrations of CC-122. Cells are cultured for 5 days at 37 degrees Celsius after which tritiated thymidine is added to the cell culture for the final 6 hours. Cells are subsequently harvested onto filter plates. After the plates have dried, scintillation fluid is added to the plates and read on a Top-count reader(Only for Reference)
Synonyms CC 122
Molecular Weight 286.29
Formula C14H14N4O3
CAS No. 1015474-32-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 1 mg/mL (3.49 mM)

DMSO: 52 mg/mL(181.7 mM)

TargetMolReferences and Literature

1. Hagner PR, et al. Blood. 2015, 126(6):779-89.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Clinical Compound Library Orally Active Compound Library NO PAINS Compound Library Anti-Aging Compound Library Bioactive Compounds Library Max Ubiquitination Compound Library Immunology/Inflammation Compound Library

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Keywords

Avadomide 1015474-32-4 Apoptosis PROTAC Ubiquitination E1/E2/E3 Enzyme Ligand for E3 Ligase orally diffuse CC122 CC-122 B-cell Inhibitor DLBCL Ubiquitin ligase E3 ligating enzyme immunomodulatory cereblon E1 activating enzyme ligase E2 conjugating enzyme large CC 122 Ubiquitin conjugating enzyme Ubiquitin activating enzyme antitumor inhibit lymphoma inhibitor

 

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