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Camostat mesylate

Catalog No. T2391 CAS 59721-29-8

Synonyms: FOY-S980, FOY305, Camostat mesilate

Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.

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Camostat mesylate, CAS 59721-29-8

Pack Size	Availability	Price/USD
10 mg	In stock	$ 43.00
25 mg	In stock	$ 66.00
50 mg	In stock	$ 89.00
100 mg	In stock	$ 125.00
200 mg	In stock	$ 185.00
500 mg	In stock	$ 313.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 100%

Purity: 99.69%

Purity: 99.31%

Purity: 98.17%

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Storage & Solubility Information

Description	Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.
Targets&IC50	ENaC:50 nM
In vitro	Camostat mesilate, at a concentration of 1 mg/g, is effective in preventing pancreatic atrophy and improving exocrine function in rats with DBTC-induced chronic pancreatitis. This compound also inhibits chronic inflammation and fibrosis in the pancreas caused by DBTC. It suppresses the development of pancreatic fibrosis and PSC activation, as well as monocyte infiltration and the expression of MCP-1 in serum and pancreatic tissues. When administered at a dose of 100 mg/kg, Camostat mesilate significantly increases body and pancreatic wet weight, and effectively reduces inflammatory changes and fibrosis in the pancreas by inhibiting gene expression of PAP, p8, and cytokines in chronic pancreatitis. In rats treated with pig serum, Camostat mesilate (1-2 mg/g in diet) notably decreases the levels of hepatic plasmin and TGF-β and inhibits HSC activation and liver fibrosis, without noticeable systemic or local side effects. Additionally, at a dose of 100 μg/kg intratracheally, Camostat prolongs the attenuation of ENaC activity in guinea pig tracheas.
In vivo	At a concentration of 2 mM, Camostat mesilate inhibits the production of MCP-1 and TNF-α in activated rat monocytes and the proliferation of rat pancreatic stellate cells (PSCs) along with MCP-1 production. In the presence of 20 mM Camostat mesilate, there is a notable reduction in blood glucose levels when combined with insulin and administered via the large intestine, effectively decreasing insulin degradation in the rat's small intestine and its homogenate. A 30 μM concentration of Camostat prolongs the decay of ENaC function in a human respiratory epithelial cell model, which can be reversed by adding excess trypsin. At 500 mM, Camostat mesilate inhibits the generation of TGF-β by suppressing plasmin activity and reduces the activity of TGF-beta, thereby blocking the ex vivo activation of hepatic stellate cells (HSC).

Synonyms	FOY-S980, FOY305, Camostat mesilate
Molecular Weight	494.52
Formula	C21H26N4O8S
CAS No.	59721-29-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 49.5 mg/mL (100 mM)

H2O: 49.5 mg/mL (100 mM)

References and Literature

1. Coote K, et al. J Pharmacol Exp Ther, 2009, 329(2), 764-774. 2. Okuno M, et al. Gastroenterology, 2001, 120(7), 1784-1800. 3. Yamamoto A, et al. Pharm Res, 1994, 11(10), 1496-1500. 4. Gibo J, et al. Lab Invest, 2005, 85(1), 75-89. 5. Su SB, et al. Pancreas, 2001, 23(2), 134-140.

Citations

1. Zhang S, Gao C, Das T, et al. The spike-ACE2 binding assay: An in vitro platform for evaluating vaccination efficacy and for screening SARS-CoV-2 inhibitors and neutralizing antibodies. Journal of Immunological Methods. 2022: 113244.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Cancer Drug Library Membrane Protein-targeted Compound Library Drug Repurposing Compound Library FDA-Approved Kinase Inhibitor Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Inhibitor Library Kinase Inhibitor Library Approved Drug Library

Related Products

Related compounds with same targets

6-(Dimethylamino)purine CRT0066101 dihydrochloride CRT0066101 1-NM-PP1 CID-797718 GAK inhibitor 49 MLCK inhibitor peptide 18 acetate TAO Kinase inhibitor 2

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Keywords

Camostat mesylate 59721-29-8 Cell Cycle/Checkpoint Membrane transporter/Ion channel Metabolism Microbiology/Virology SARS-CoV Serine/threonin kinase Sodium Channel pancreatitis Serine proteases Camostat Mesylate chronic Threonine proteases inhibit virus FOY-S 980 FOY-S-980 Serine endopeptidases SARS coronavirus Ser/Thr Protease oral coronavirus FOY-S980 TMPRSS2 Camostat FOY305 FOY 305 Inhibitor FOY-305 Camostat mesilate inhibitor

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