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Cladribine
🥰Excellent
Catalog No. T2558Cas No. 4291-63-8
Alias CldAdo, 2-chlorodeoxyadenosine, 2-Chloro-2′-deoxyadenosine, 2CdA
Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.
Cladribine
🥰Excellent
Purity: 100%
Catalog No. T2558Alias CldAdo, 2-chlorodeoxyadenosine, 2-Chloro-2′-deoxyadenosine, 2CdACas No. 4291-63-8
Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $34 | In Stock | |
| 10 mg | $50 | In Stock | |
| 50 mg | $72 | In Stock | |
| 100 mg | $117 | In Stock | |
| 200 mg | $175 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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CitedSelect Batch
Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases. |
| Targets&IC50 | Adenosine deaminase (U266 cells):2.43 μM, Adenosine deaminase (MM1.S cells):0.18 μM, Adenosine deaminase (RPMI8226 cells):0.75 μM |
| In vitro | In adult zebrafish, intraperitoneal injection of Cladribine (0.7-3.5 mM) was found to inhibit the concentration levels of ATP in RBCs (Red Blood Cells). |
| In vivo | Cladribine inhibits cell growth in primary mast cells (MC) and the MC line HMC-1. It also reduces cell migration ability in CD14+ monocytes as well as CD4+ and CD8+ T lymphocytes. Additionally, Cladribine suppresses cell proliferation in U266, RPMI8226, and MM1.S cells in a dose-dependent manner. |
| Cell Research | The non-radioactive cell proliferation kit is used to determine cell viability. In brief, Human MM cell line U266, RPMI8226 and MM1.S are seeded onto 96-well plates with either 0.1 mL complete medium (5% FBS) as control, or 0.1 mL of the same medium containing a series of doses of cladribine, and incubated for 72 hours. After reading all wells at 490 nm with a micro-plate reader, the percentages of surviving cells from each group relative to controls, defined as 100% survival, are determined by reduction of MTS.(Only for Reference) |
| Alias | CldAdo, 2-chlorodeoxyadenosine, 2-Chloro-2′-deoxyadenosine, 2CdA |
| Molecular Weight | 285.69 |
| Formula | C10H12ClN5O3 |
| Cas No. | 4291-63-8 |
| Smiles | Nc1nc(Cl)nc2n(cnc12)[C@H]1C[C@H](O)[C@@H](CO)O1 |
| Relative Density. | 2.03g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 55 mg/mL (192.52 mM)  H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
tissuesclerosismultiplemucosa-associatedMCLmantleMALTlymphomalymphoidlymphocyticleukemiaInhibitorinhibitHCLhairyfollicularDLBCLCLLCladribinechroniccellApoptosisAdenosinedeaminaseAdenosine deaminase (U266 cells)Adenosine deaminase (RPMI8226 cells)Adenosine deaminase (MM1.S cells)Adenosine DeaminaseAdenosine deaminase
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