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Cladribine

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Purity:100%

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COA LCMS HNMR

Cladribine

Catalog No. T2558Cas No. 4291-63-8

Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.

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Pack Size	Price	Availability
5 mg	$34	In Stock
10 mg	$50	In Stock
50 mg	$72	In Stock
100 mg	$117	In Stock
200 mg	$175	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Product Introduction

Bioactivity

Description	Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.
In vitro	In adult zebrafish, intraperitoneal injection of Cladribine (0.7-3.5 mM) was found to inhibit the concentration levels of ATP in RBCs (Red Blood Cells).
In vivo	Cladribine inhibits cell growth in primary mast cells (MC) and the MC line HMC-1. It also reduces cell migration ability in CD14+ monocytes as well as CD4+ and CD8+ T lymphocytes. Additionally, Cladribine suppresses cell proliferation in U266, RPMI8226, and MM1.S cells in a dose-dependent manner.
Cell Research	The non-radioactive cell proliferation kit is used to determine cell viability. In brief, Human MM cell line U266, RPMI8226 and MM1.S are seeded onto 96-well plates with either 0.1 mL complete medium (5% FBS) as control, or 0.1 mL of the same medium containing a series of doses of cladribine, and incubated for 72 hours. After reading all wells at 490 nm with a micro-plate reader, the percentages of surviving cells from each group relative to controls, defined as 100% survival, are determined by reduction of MTS.(Only for Reference)
Alias	2-chlorodeoxyadenosine, 2-Chloro-2′-deoxyadenosine, CldAdo, 2CdA

Chemical Properties

Molecular Weight	285.69
Formula	C10H12ClN5O3
Cas No.	4291-63-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 55 mg/mL (192.52 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5003 mL	17.5015 mL	35.0030 mL	175.0149 mL
5 mM	0.7001 mL	3.5003 mL	7.0006 mL	35.0030 mL
10 mM	0.3500 mL	1.7501 mL	3.5003 mL	17.5015 mL
20 mM	0.1750 mL	0.8751 mL	1.7501 mL	8.7507 mL
50 mM	0.0700 mL	0.3500 mL	0.7001 mL	3.5003 mL
100 mM	0.0350 mL	0.1750 mL	0.3500 mL	1.7501 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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