Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 34.00 | |
10 mg | In stock | $ 50.00 | |
50 mg | In stock | $ 72.00 | |
100 mg | In stock | $ 117.00 | |
200 mg | In stock | $ 175.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases. |
Targets&IC50 | Adenosine deaminase (U266 cells):2.43 μM, Adenosine deaminase (MM1.S cells):0.18 μM, Adenosine deaminase (RPMI8226 cells):0.75 μM |
In vitro | In adult zebrafish, intraperitoneal injection of Cladribine (0.7-3.5 mM) was found to inhibit the concentration levels of ATP in RBCs (Red Blood Cells). |
In vivo | Cladribine inhibits cell growth in primary mast cells (MC) and the MC line HMC-1. It also reduces cell migration ability in CD14+ monocytes as well as CD4+ and CD8+ T lymphocytes. Additionally, Cladribine suppresses cell proliferation in U266, RPMI8226, and MM1.S cells in a dose-dependent manner. |
Cell Research | The non-radioactive cell proliferation kit is used to determine cell viability. In brief, Human MM cell line U266, RPMI8226 and MM1.S are seeded onto 96-well plates with either 0.1 mL complete medium (5% FBS) as control, or 0.1 mL of the same medium containing a series of doses of cladribine, and incubated for 72 hours. After reading all wells at 490 nm with a micro-plate reader, the percentages of surviving cells from each group relative to controls, defined as 100% survival, are determined by reduction of MTS.(Only for Reference) |
Synonyms | 2-chlorodeoxyadenosine, 2-Chloro-2′-deoxyadenosine, CldAdo, 2CdA |
Molecular Weight | 285.69 |
Formula | C10H12ClN5O3 |
CAS No. | 4291-63-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 53 mg/mL (185.5 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Cladribine 4291-63-8 Apoptosis Metabolism Adenosine deaminase HCL multiple Adenosine Deaminase 2-chlorodeoxyadenosine leukemia lymphoma follicular MALT cell MCL DLBCL chronic Inhibitor hairy 2-Chloro-2′-deoxyadenosine CldAdo 2CdA mucosa-associated tissue mantle lymphoid sclerosis CLL lymphocytic inhibit inhibitor