Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dabuzalgron (Ro 115-1240) is an orally active selective alpha-1A adrenergic receptor agonist used to treat urinary incontinence. Dabuzaron prevents cardiotoxicity caused by doxorubicin by maintaining mitochondrial function.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 53.00 | |
5 mg | In stock | $ 126.00 | |
10 mg | In stock | $ 228.00 | |
25 mg | In stock | $ 370.00 | |
50 mg | In stock | $ 555.00 | |
100 mg | In stock | $ 798.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 139.00 |
Description | Dabuzalgron (Ro 115-1240) is an orally active selective alpha-1A adrenergic receptor agonist used to treat urinary incontinence. Dabuzaron prevents cardiotoxicity caused by doxorubicin by maintaining mitochondrial function. |
In vitro | Dabuzaron treatment increased ERK phosphorylation in a dose-dependent manner with an EC50 of 4.8 μM. ERK1 / 2 activation helps Dabuzaron's cardioprotection. Dabuzaron (10 μM; 4 hours) protects NRVM from cell death caused by doxorubicin (DOX). Dabuzaren (10 μM; 4 hours) activation of α1A-AR alleviates the harmful effects of DOX on mitochondrial membrane potential and eliminates the activation of important elements of the apoptotic response to mitochondrial damage. |
In vivo | Dabuzaron (10μg / kg; oral tube; twice daily; 7 consecutive days; C57B16J wild-type or α1A-AR gene knockout mice) treatment can prevent DOX cardiotoxicity by activating α1A-AR. Dabuzaron prevents mitochondrial function-related transcript reduction, up-regulates PGC1α, retains ATP content, and reduces oxidative stress in DOX-treated mouse hearts. |
Synonyms | Ro 115-1240 |
Molecular Weight | 317.79 |
Formula | C12H16ClN3O3S |
CAS No. | 219311-44-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL(78.67 mM)
You can also refer to dose conversion for different animals. More
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Dabuzalgron 219311-44-1 Apoptosis GPCR/G Protein Neuroscience Adrenergic Receptor membrane potential inhibit mitochondrial urinary Inhibitor Beta Receptor incontinence Cell death Ro 115-1240 inhibitor