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Diphenmanil methylsulfate

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Purity:98%

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COA HNMR

Diphenmanil methylsulfate

Catalog No. T0594Cas No. 62-97-5

Diphenmanil methylsulfate (Diphemanil mesylate), a quaternary ammonium anticholinergic, binds muscarinic acetylcholine receptors and thus decreases secretory excretion of stomach acids, sweat, and saliva.

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Pack Size	Price	Availability
10 mg	$40	In Stock
25 mg	$63	In Stock
50 mg	$79	In Stock
100 mg	$103	In Stock
200 mg	$151	In Stock
500 mg	$249	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Product Introduction

Bioactivity

Description	Diphenmanil methylsulfate (Diphemanil mesylate), a quaternary ammonium anticholinergic, binds muscarinic acetylcholine receptors and thus decreases secretory excretion of stomach acids, sweat, and saliva.
In vitro	Pharmacokinetic studies indicate that Diphemanil Methylsulphate is slowly absorbed, with a peak time (tmax) of 2-4 hours and an average half-life of 8.35 hours. Within 48 hours, 0.6%-7.4% of the administered dose is recovered in the urine. The compound exhibits poor gastrointestinal absorption, with bioavailability ranging from 15% to 25%.
In vivo	Diphemanil Methylsulfate exerts its anticholinergic effects primarily by binding to muscarinic M3 receptors, and it also acts directly on smooth muscle to provide antispasmodic benefits.
Alias	Diphemanil mesylate, Diphemanil Methylsulfate

Chemical Properties

Molecular Weight	389.51
Formula	C20H24N·CH3O4S
Cas No.	62-97-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (128.37 mM), Sonication is recommended.

H2O: 26 mg/mL (66.8 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5673 mL	12.8366 mL	25.6733 mL	128.3664 mL
5 mM	0.5135 mL	2.5673 mL	5.1347 mL	25.6733 mL
10 mM	0.2567 mL	1.2837 mL	2.5673 mL	12.8366 mL
20 mM	0.1284 mL	0.6418 mL	1.2837 mL	6.4183 mL
50 mM	0.0513 mL	0.2567 mL	0.5135 mL	2.5673 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0257 mL	0.1284 mL	0.2567 mL	1.2837 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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