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Dronedarone

Catalog No. T7056 CAS 141626-36-0

Synonyms: SR 33589

Dronedarone is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.

Dronedarone, CAS 141626-36-0

Pack Size	Availability	Price/USD
1 mg	In stock	30.00
10 mg	In stock	59.00
50 mg	In stock	172.00

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Purity 98.85%

HNMR HPLC COA Datasheet MSDS

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Storage & Solubility Information

Description	Dronedarone is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
Targets&IC50
In vivo	Dronedarone increases action potential duration in normal hearts of rats. Dronedarone reduces the late sustained K(+) current, I(K) (or Isus) by 69%. Dronedarone induces only a tonic block of I(K). Dronedarone induces a weak increase in the fast transient outward current, I(to), in rats after myocardial infarction [4].

Synonyms	SR 33589
Purity	98.85%
Molecular Weight	556.76
Formula	C31H44N2O5S
CAS No.	141626-36-0

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 27.8mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Varró A, et al. Electrophysiological effects of dronedarone (SR 33589), a noniodinated amiodarone derivative in the canine heart: comparison with amiodarone.[J]. Br J Pharmacol, 2010, 133(5):625-634. 2. Altomare C, et al. Effects of dronedarone on Acetylcholine-activated current in rabbit SAN cells[J]. British Journal of Pharmacology, 2010, 130(6):1315-1320. 3. Bogdan R, et al. Effect of dronedarone on Na+, Ca2+ and HCN channels[J]. Naunyn-Schmiedeberg's Archives of Pharmacology, 2011, 383(4):347-356. 4. Aimond F, et al. Cellular and in vivo electrophysiological effects of dronedarone in normal and postmyocardial infarcted rats.[J]. Journal of Pharmacology & Experimental Therapeutics, 2000, 292(1):415.

Related compound libraries

This product is contained In the following compound libraries：

Natural Compound Library for HTS

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