Home Tools

Dronedarone

Catalog No. T7056 CAS 141626-36-0

Synonyms: SR 33589

Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Dronedarone, CAS 141626-36-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 30.00
10 mg	In stock	$ 47.00
25 mg	In stock	$ 86.00
50 mg	In stock	$ 138.00
100 mg	In stock	$ 198.00
1 mL * 10 mM (in DMSO)	In stock	$ 52.00

Bulk Inquiry

Select Batch

Purity: 99.58%

Purity: 99.55%

Purity: 98.85%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
In vitro	Dronedarone reduces the incidence of early and delayed after depolarizations evoked by 1 mM Dofetilide and 0.2 mM Strophantidine in Purkinje fibres. Dronedarone (10 mM) markedly reduces the L-type calcium current (76.5%) and the rapid component of the delayed rectifier potassium current (97%) in ventricular myocytes [1]. Dronedarone inhibits the activity of I(K(ACh)) channels recorded from cell-attached patches by reducing the channel open probability (from 0.56 to 0.11) without modification of the single-channel conductance in single cells isolated from sinoatrial node (SAN) tissue of rabbit hearts [2]. Dronedarone exhibits a state-dependent inhibition of the fast Na(+) channel current with an IC50 of 0.7 μM in guinea pig ventricular myocytes, when the holding potential (V (hold)) is -80 mV. Dronedarone blocks Ca(2+) currents elicited by rectangular pulses at V (hold)?=?-40 mV with IC50 value of 0.4 μM, whereas at V (hold)?=?-80 mV, Dronedarone (10 μM) blocks only 20?% of the current [3].
In vivo	Dronedarone increases action potential duration in normal hearts of rats. Dronedarone reduces the late sustained K(+) current, I(K) (or Isus) by 69%. Dronedarone induces only a tonic block of I(K). Dronedarone induces a weak increase in the fast transient outward current, I(to), in rats after myocardial infarction [4].

Synonyms	SR 33589
Molecular Weight	556.76
Formula	C31H44N2O5S
CAS No.	141626-36-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.8 mg/mL

References and Literature

1. Varró A, et al. Electrophysiological effects of dronedarone (SR 33589), a noniodinated amiodarone derivative in the canine heart: comparison with amiodarone.[J]. Br J Pharmacol, 2010, 133(5):625-634. 2. Altomare C, et al. Effects of dronedarone on Acetylcholine-activated current in rabbit SAN cells[J]. British Journal of Pharmacology, 2010, 130(6):1315-1320. 3. Bogdan R, et al. Effect of dronedarone on Na+, Ca2+ and HCN channels[J]. Naunyn-Schmiedeberg's Archives of Pharmacology, 2011, 383(4):347-356. 4. Aimond F, et al. Cellular and in vivo electrophysiological effects of dronedarone in normal and postmyocardial infarcted rats.[J]. Journal of Pharmacology & Experimental Therapeutics, 2000, 292(1):415.

Citations

1. Cui R, Zhang J, Liu X, et al.Dronedarone Enhances the Antibacterial Activity of Polymyxin B and Inhibits the Quorum Sensing System by Interacting with LuxS.ACS Infectious Diseases.2024

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library GPCR Compound Library Inhibitor Library EMA Approved Drug Library Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Microbial Natural Product Library

Related Products

Related compounds with same targets

Bifonazole N-Nornuciferine Vorozole 1-Ethynylpyrene Retrorsine 3-(2-Naphthalenyl)-1-(3-pyridinyl)-2-propen-1-one Talarozole Fraxinol

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Dronedarone 141626-36-0 Autophagy GPCR/G Protein Membrane transporter/Ion channel Metabolism Neuroscience Sodium Channel Adrenergic Receptor AChR Calcium Channel P450 Potassium Channel inoatrial nodal atrial myocyte Beta Receptor SR33589 Cytochrome P450 atrial flutter inhibit Ca channels mAChR Inhibitor Na channels coronary perfusion CYPs Muscarinic acetylcholine receptor Na+ channels SR-33589 antiadrenergic potassium current SR 33589 Ca2+ channels inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.