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Dronedarone hydrochloride (SR33589) is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | 30 € | In Stock | |
10 mg | 45 € | In Stock | |
25 mg | 75 € | In Stock | |
50 mg | 113 € | In Stock | |
100 mg | 169 € | In Stock | |
200 mg | 249 € | In Stock | |
500 mg | 424 € | In Stock | |
1 mL x 10 mM (in DMSO) | 47 € | In Stock |
Description | Dronedarone hydrochloride (SR33589) is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation. |
In vitro | Dronedarone reduces the incidence of early and delayed after depolarizations evoked by 1 mM Dofetilide and 0.2 mM Strophantidine in Purkinje fibres. Dronedarone (10 mM) markedly reduces the L-type calcium current (76.5%) and the rapid component of the delayed rectifier potassium current (97%) in ventricular myocytes. [1] Dronedarone inhibits the activity of I(K(ACh)) channels recorded from cell-attached patches by reducing the channel open probability (from 0.56 to 0.11) without modification of the single-channel conductance in single cells isolated from sinoatrial node (SAN) tissue of rabbit hearts. [2] Dronedarone exhibits a state-dependent inhibition of the fast Na(+) channel current with an IC50 of 0.7 μM in guinea pig ventricular myocytes, when the holding potential (V (hold)) is -80 mV. Dronedarone blocks Ca(2+) currents elicited by rectangular pulses at V (hold) = -40 mV with IC50 value of 0.4 μM, whereas at V (hold) = -80 mV, Dronedarone (10 μM) blocks only 20 % of the current. [3] |
In vivo | Dronedarone increases action potential duration in normal hearts of rats. Dronedarone reduces the late sustained K(+) current, I(K) (or Isus) by 69%. Dronedarone induces only a tonic block of I(K). Dronedarone induces a weak increase in the fast transient outward current, I(to), in rats after myocardial infarction. [4] |
Alias | SR33589, Dronedarone HCl |
Molecular Weight | 593.22 |
Formula | C31H44N2O5S·HCl |
Cas No. | 141625-93-6 |
Smiles | Cl.CS(=O)(=O)Nc1cc2c(c(oc2cc1)CCCC)C(=O)c1ccc(cc1)OCCCN(CCCC)CCCC |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (101.14 mM) Ethanol: 38 mg/mL (64.1 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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