Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dronedarone hydrochloride (SR33589) is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 32.00 | |
10 mg | In stock | $ 48.00 | |
25 mg | In stock | $ 88.00 | |
50 mg | In stock | $ 138.00 | |
100 mg | In stock | $ 198.00 | |
200 mg | In stock | $ 296.00 | |
500 mg | In stock | $ 498.00 | |
1 g | In stock | $ 725.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Dronedarone hydrochloride (SR33589) is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation. |
In vitro | Dronedarone reduces the incidence of early and delayed after depolarizations evoked by 1 mM Dofetilide and 0.2 mM Strophantidine in Purkinje fibres. Dronedarone (10 mM) markedly reduces the L-type calcium current (76.5%) and the rapid component of the delayed rectifier potassium current (97%) in ventricular myocytes. [1] Dronedarone inhibits the activity of I(K(ACh)) channels recorded from cell-attached patches by reducing the channel open probability (from 0.56 to 0.11) without modification of the single-channel conductance in single cells isolated from sinoatrial node (SAN) tissue of rabbit hearts. [2] Dronedarone exhibits a state-dependent inhibition of the fast Na(+) channel current with an IC50 of 0.7 μM in guinea pig ventricular myocytes, when the holding potential (V (hold)) is -80 mV. Dronedarone blocks Ca(2+) currents elicited by rectangular pulses at V (hold) = -40 mV with IC50 value of 0.4 μM, whereas at V (hold) = -80 mV, Dronedarone (10 μM) blocks only 20 % of the current. [3] |
In vivo | Dronedarone increases action potential duration in normal hearts of rats. Dronedarone reduces the late sustained K(+) current, I(K) (or Isus) by 69%. Dronedarone induces only a tonic block of I(K). Dronedarone induces a weak increase in the fast transient outward current, I(to), in rats after myocardial infarction. [4] |
Synonyms | Dronedarone HCl, SR33589 |
Molecular Weight | 593.22 |
Formula | C31H44N2O5S·HCl |
CAS No. | 141625-93-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 74 mg/mL (124.7 mM)
Ethanol: 38 mg/mL (64.1 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
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