Powder: -20°C for 3 years
In solvent: -80°C for 2 years
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).
Description | GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested). |
Targets&IC50 | mTOR (p70S6K):1000nM, RSK1:398 nM |
Synonyms | GSK25, GSK 25 |
Molecular Weight | 513.33 |
Formula | C24H16Cl2F2N6O |
CAS No. | 874119-56-9 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 10 mM
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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GSK-25 874119-56-9 MAPK信号通路 PI3K/Akt/mTOR信号通路 干细胞 细胞骨架 细胞周期 mTOR ROCK S6 Kinase Rho-associated kinase ROK Rho-associated protein kinase S6K bioavailable Ribosomal S6 Kinase (RSK) Rho-kinase Inhibitor p70S6K selective pressure P450 GSK25 inhibit GSK 25 blood orally inhibitor