Search Result

Search Results for " bioavailable "

Targets

538

Compounds

Natural Products

Cat No.	Product Name	Synonyms	Targets
T9497	Niraparib tosylate monohyrate		PARP
	Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting...		PARP
T39695	ARD-2128		Androgen Receptor
	ARD-2128 is a highly potent, orally bioavailable PROTAC (proteolysis-targeting chimera) degrader of the androgen receptor (AR), effectively diminishing AR protein levels, suppressing AR-regulated gene expression in tumor...		Androgen Receptor
T12266	Ilginatinib	NS-018	Tyrosine Kinases , JAK
	Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2.		Tyrosine Kinases , JAK
T5414	Glumetinib	SCC244	c-Met/HGFR
	Glumetinib (SCC244) (SCC 244) is a novel potent and selective inhibitor of c-Met kinase (IC50: 0.42 nM).		c-Met/HGFR
T12266L2	Ilginatinib hydrochloride	NS-018 hydrochloride	Tyrosine Kinases , JAK
	Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.		Tyrosine Kinases , JAK
T12266L	Ilginatinib maleate	NS-018 maleate	Tyrosine Kinases , JAK
	Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.		Tyrosine Kinases , JAK
T4488	GSK-25	GSK25	ROCK , S6 Kinase , mTOR
	GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).		ROCK , S6 Kinase , mTOR
T3231	Niraparib	MK-4827	Apoptosis , Others , PARP
	Niraparib (MK-4827) is a PARP inhibitor that selectively inhibits PARP1 and PARP2 (IC50=3.8/2.1 nM). Niraparib has antitumor activity, inhibits DNA damage repair, and induces apoptosis.		Apoptosis , Others , PARP
T6714	URB-597	KDS-4103,FAAH Inhibitor II	Mitophagy , FAAH , Autophagy
	URB-597 (FAAH Inhibitor II) is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.		Mitophagy , FAAH , Autophagy
T6041	Oprozomib	PR-047,ONX 0912	Proteasome , Autophagy
	Oprozomib (PR-047) (ONX 0912) , an inhibitor for CT-L activity of 20S proteasome β5(IC50=36 nM)/LMP7(IC50=82 nM), is orally bioavailable. Oprozomib also has potential antineoplastic activity.		Proteasome , Autophagy
T2119	Venetoclax	GDC-0199,ABT 199,ABT-199,ABT199	BCL , Autophagy
	Venetoclax (ABT-199) is a Bcl-2 inhibitor (Ki<0.01 nM) with potent, selective, and orally active properties. Venetoclax has a 3-order-of-magnitude lower affinity for Bcl-xL and Bcl-W (Kis=48/245 nM). Venetoclax induces a...		BCL , Autophagy
T17225	Vercirnon	CCX282-B,GSK-1605786,Traficet-EN	CCR
	Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.		CCR
T9146	Ms48107	Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro-	Others
	MS48107 is a potent, selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68), demonstrating specificity for GPR68 over closely related proton GPCRs, neurotransmitter transporters, and hERG ion ch...		Others
T3353	Niraparib hydrochloride	MK-4827 hydrochloride,MK-4827 (hydrochloride)	Apoptosis , Others , PARP
	Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Niraparib hydrochloride inhibits PARP activity, enhancing the accumulation of...		Apoptosis , Others , PARP
T6892	Niraparib tosylate	MK-4827 (tosylate),MK 4827 tosylate,Niraparib (MK-4827) tosylate	Apoptosis , PARP
	Niraparib tosylate (MK-4827 (tosylate))(with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor.		Apoptosis , PARP
T26174	SAK3	SAK-3,SAK 3
	SAK 3 is a potent and orally bioavailable CaV3.1/3.3 activator.
T39573	GSK251		PI3K
	GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.		PI3K
T17218	Varespladib methyl	A-002,LY333013	Others , Phospholipase
	Varespladib methyl (LY333013), a bioavailable prodrug of Varespladib, is a selective group II secretory phospholipase A2 inhibitor.		Others , Phospholipase
T10300	AMG2850		TRP/TRPV Channel
	AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).		TRP/TRPV Channel
T11226	ERK1/2 inhibitor 1		ERK
	ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.		ERK
T12847	SB-616234-A	SB-616234A	5-HT Receptor
	SB-616234A is a selective and orally bioavailable antagonist of 5-HT1B receptor, with anxiolytic and antidepressant activity.		5-HT Receptor
T2351	Fasiglifam	TAK875	GPR
	Fasiglifam (TAK875) is a potent, selective and orally bioavailable GPR40 agonist.		GPR
T5417	INCB-057643		Apoptosis , Epigenetic Reader Domain
	INCB057643 is a potent, selective and orally bioavailable BET inhibitor.		Apoptosis , Epigenetic Reader Domain
T4510	Polaprezinc	Zinc L-carnosine	Others
	Polaprezinc is an bioavailable chelate comprised of zinc and L-carnosine, known for its gastrointestinal protective properties, as well as its anti-ulcer, antioxidant, and anti-inflammatory effects.		Others
TQ0029	ASTX660		IAP
	ASTX660 is an orally bioavailable dual antagonist of cIAP and XIAP.		IAP
T3389	Antitumor agent-21	TRX818	Others
	Antitumor agent-21 (TRX818) is an orally bioavailable agent with potential antineoplastic and anti-vasculogenic mimicry (VM) activities.		Others
T17179	Tulrampator	CX-1632,S-47445	iGluR
	Tulrampator (S-47445) is an orally bioavailable positive AMPAR with antidepressant effects.		iGluR
T16776	RO9021		Syk
	RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).		Syk
TQ0069	MI-503		Epigenetic Reader Domain , Histone Methyltransferase
	MI-503 is a highly effective and orally bioavailable inhibitor of the menin-mLL interaction.		Epigenetic Reader Domain , Histone Methyltransferase
T2360	Baricitinib phosphate	Baricitinib Phosphate,LY3009104,INCB-028050 phosphate,LY-3009104 phosphate,INCB028050	Tyrosine Kinases , JAK
	Baricitinib phosphate (INCB028050) is a selective orally bioavailable JAK1/JAK2 inhibitor.		Tyrosine Kinases , JAK
T20454	4-Chlorophenylurea	NSC12971,NSC 12971,NSC-12971	Factor Xa
	4-Chlorophenylurea (NSC-12971) is a novel orally bioavailable inhibitor of factor Xa.		Factor Xa
T14901	CCT-251921		CDK
	CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).		CDK
T6123	Verdinexor	KPT-335	CRM1
	Verdinexor (KPT-335) (KPT-335), a specific XPO1/CRM1 inhibitor, are orally bioavailable.		CRM1
T3544	SHP099 hydrochloride		Phosphatase , Others
	SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor.		Phosphatase , Others
T4490	PF-01247324		Sodium Channel
	PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker (IC50: 196 nM).		Sodium Channel
T12395	PDE9-IN-1		PDE
	PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).		PDE
T2259	Silmitasertib	CX-4945	Casein Kinase , Autophagy
	Silmitasertib (CX-4945) is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).		Casein Kinase , Autophagy
T6692	TAK-733	TAK733,TAK 733	MEK
	TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.		MEK
T6965	RG7112	RG-7112,RG 7112,RO5045337	Mdm2 , E1/E2/E3 Enzyme
	RG7112 (RO5045337) (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.		Mdm2 , E1/E2/E3 Enzyme
TQ0229	ETP-46321		PI3K
	ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).		PI3K
T6101	Entospletinib	GS-9973	Syk
	Entospletinib (GS-9973) (IC50= 7.7 nM)is a specific Syk inhibitor, which is orally bioavailable.		Syk
T5555	Siremadlin	NVP-HDM 201	E1/E2/E3 Enzyme
	Siremadlin (NVP-HDM 201) is a potent, orally bioavailable and highly specific p53-MDM2 interaction inhibitor.		E1/E2/E3 Enzyme
T11444	GNF-6231		Porcupine
	GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.		Porcupine
T6044	Telotristat Etiprate	LX1606 (Hippurate),LX 1606 Hippurate	Hydroxylase
	Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.		Hydroxylase
T1961	Vistusertib	AZD2014	Apoptosis , Akt , PI3K , S6 Kinase , mTOR , Autophagy
	Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.		Apoptosis , Akt , PI3K , S6 Kinase , mTOR , Autophagy
T6053	Turofexorate Isopropyl	XL335,FXR-450,WAY-362450	FXR , Autophagy
	Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM		FXR , Autophagy
T6117	Tivantinib	ARQ 197	Apoptosis , c-Met/HGFR
	Tivantinib (ARQ 197) is an orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity.		Apoptosis , c-Met/HGFR
T10929L	D-3263 hydrochloride	EC D-3263 HCl,D3263 HCl salt	TRP/TRPV Channel
	D-3263 hydrochloride (D3263 HCl salt) is enteric-coated, orally bioavailable transient receptor potential melatonin member 8 (TRPM8) agonist.		TRP/TRPV Channel
T7667	R1487		p38 MAPK
	R1487 is an orally bioavailable and highly selective p38α mitogen-activated protein kinase inhibitor.		p38 MAPK
T12431	PF-06882961		Glucagon Receptor
	PF-06882961 is an orally bioavailable glucagon-like peptide-1 receptor (GLP-1R) agonist.		Glucagon Receptor

Compounds

Niraparib tosylate monohyrate

Target: Androgen Receptor

Ilginatinib

T12266

Synonym: NS-018

Target: Tyrosine Kinases, JAK

Ilginatinib hydrochloride

T12266L2

Synonym: NS-018 hydrochloride

Target: Tyrosine Kinases, JAK

Ilginatinib maleate

T12266L

Synonym: NS-018 maleate

Target: Tyrosine Kinases, JAK

GSK-25

T4488

Synonym: GSK25

Target: ROCK, S6 Kinase, mTOR

Niraparib

T3231

Synonym: MK-4827

Target: Apoptosis, Others, PARP

URB-597

T6714

Synonym: KDS-4103,FAAH Inhibitor II

Target: Mitophagy, FAAH, Autophagy

Oprozomib

T6041

Synonym: PR-047,ONX 0912

Target: Proteasome, Autophagy

Venetoclax

T2119

Synonym: GDC-0199,ABT 199,ABT-199,ABT199

Target: BCL, Autophagy

Vercirnon

T17225

Synonym: CCX282-B,GSK-1605786,Traficet-EN

Target: CCR

ms48107

T9146

Synonym: Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro-

Target: Others

Niraparib hydrochloride

T3353

Synonym: MK-4827 hydrochloride,MK-4827 (hydrochloride)

Target: Apoptosis, Others, PARP

Niraparib tosylate

T6892

Synonym: MK-4827 (tosylate),MK 4827 tosylate,Niraparib (MK-4827) tosylate

Target: Apoptosis, PARP

Synonym: A-002,LY333013

Target: Others, Phospholipase

AMG2850

T10300

Synonym:

Target: TRP/TRPV Channel

Target: 5-HT Receptor

Target: Apoptosis, Epigenetic Reader Domain

Polaprezinc

T4510

Synonym: Zinc L-carnosine

Synonym: CX-1632,S-47445

Target: Epigenetic Reader Domain, Histone Methyltransferase

Baricitinib phosphate

T2360

Synonym: Baricitinib Phosphate,LY3009104,INCB-028050 phosphate,LY-3009104 phosphate,INCB028050

Target: Tyrosine Kinases, JAK

4-Chlorophenylurea

T20454

Synonym: NSC12971,NSC 12971,NSC-12971

Target: Phosphatase, Others

PF-01247324

T4490

Synonym:

Target: Sodium Channel

Target: Casein Kinase, Autophagy

TAK-733

T6692

Synonym: TAK733,TAK 733

Target: MEK

RG7112

T6965

Synonym: RG-7112,RG 7112,RO5045337

Target: Mdm2, E1/E2/E3 Enzyme

Target: E1/E2/E3 Enzyme

Synonym: LX1606 (Hippurate),LX 1606 Hippurate

Target: Apoptosis, Akt, PI3K, S6 Kinase, mTOR, Autophagy

Turofexorate Isopropyl

T6053

Synonym: XL335,FXR-450,WAY-362450

Target: FXR, Autophagy

Tivantinib

T6117

Synonym: ARQ 197

Target: Apoptosis, c-Met/HGFR

D-3263 hydrochloride

T10929L

Synonym: EC D-3263 HCl,D3263 HCl salt

Target: TRP/TRPV Channel

Target: Glucagon Receptor

Cat No.	Product Name	Synonyms	Targets
T2807	Caffeic Acid		Lipoxygenase , Endogenous Metabolite , TRP/TRPV Channel
	Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activities.		Lipoxygenase , Endogenous Metabolite , TRP/TRPV Channel
T13092	Tauro-Obeticholic acid		FXR
	Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).		FXR
T5041	Faropenem sodium		Antibacterial , Antibiotic
	Faropenem sodium is an orally bioavailable penem antibiotic which can efficiently kill Mycobacterium tuberculosis.It treatment of tuberculosis and community-acquired pneumonia.		Antibacterial , Antibiotic
T5113	L-GLUCOSE	L-(-)-Glucose	Others
	L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose is not bioavailable to cells as an energy source because it cannot be phosphorylated by hexokinase.		Others
T6674	L-Ascorbic acid sodium salt	(+)-Sodium L-ascorbate,Vitamin C sodium salt,Sodium ascorbate,L-Ascorbic acid sodium,Sodium L-ascorbate	Apoptosis , Others , Calcium Channel , Reactive Oxygen Species , Endogenous Metabolite
	L-Ascorbic acid sodium salt (Vitamin C sodium salt) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.
T2220	2-Methoxyestradiol	NSC-659853,2-MeOE2,2-ME2	Apoptosis , Reactive Oxygen Species , Microtubule Associated , Endogenous Metabolite , HIF , Autophagy
	2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endotheli...
T6491	(-)-(S)-Equol	(−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite
	(-)-(S)-Equol (4',7-Dihydroxyisoflavan) is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective a...