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Ritanserin
🥰Excellent
Catalog No. T16759Cas No. 87051-43-2
Alias R 55667
Ritanserin (R 55667) is a long-acting, highly potent, relatively selective, orally bioavailable 5-HT2 receptor antagonist with an IC50 of 0.9 nM.
Ritanserin
🥰Excellent
Purity: 99.89%
Catalog No. T16759Alias R 55667Cas No. 87051-43-2
Ritanserin (R 55667) is a long-acting, highly potent, relatively selective, orally bioavailable 5-HT2 receptor antagonist with an IC50 of 0.9 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $34 | In Stock | |
| 2 mg | $48 | In Stock | |
| 5 mg | $77 | In Stock | |
| 10 mg | $116 | In Stock | |
| 25 mg | $195 | In Stock | |
| 50 mg | $288 | In Stock | |
| 100 mg | $433 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $88 | In Stock |
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CitedSelect Batch
Purity:99.89%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Ritanserin (R 55667) is a long-acting, highly potent, relatively selective, orally bioavailable 5-HT2 receptor antagonist with an IC50 of 0.9 nM. |
| Targets&IC50 | 5-HT2:0.9 nM, α2-adrenoceptor:150 nM, D2:70 nM, α1-adrenoceptor:97 nM, H1:35 nM |
| In vitro | METHODS: AML cell lines Kasumi-1 and KG-1α were treated with Ritanserin (R 55667) (10, 20, 30, 40, 50, 60 μM), and cytotoxicity was determined by CCK-8. RESULTSRitanserin (R 55667) significantly reduced the proliferation activity of AML cells in a dose-dependent and time-dependent manner. [1] Ritanserin (R 55667) has low activity against multiple receptors, including histamine-H1 (IC50, 35 nM), dopamine-D2 (IC50, 70 nM), adrenergic-α1 (IC50, 97 nM), and adrenergic-α2 receptors (IC50, 150 nM).[2] |
| Alias | R 55667 |
| Molecular Weight | 477.57 |
| Formula | C27H25F2N3OS |
| Cas No. | 87051-43-2 |
| Smiles | Cc1nc2sccn2c(=O)c1CCN1CCC(CC1)=C(c1ccc(F)cc1)c1ccc(F)cc1 |
| Relative Density. | 1.3g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (104.7 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
α2 receptorα1-adrenergic receptorα1 receptorSerotonin ReceptorRitanserinR-55667R55667InhibitorinhibitHistamineReceptorHistamine ReceptorH1 receptorDopamineReceptorDopamine ReceptorDopamineD2 receptorD2Beta ReceptorAdrenergicReceptorAdrenergic Receptor5-hydroxytryptamine Receptor5HTReceptor5-HT2 receptor5-HT25-HT Receptor5HT Receptor
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